299634

6-(5H)-Phenanthridinone

technical grade

• Synonym(s): NSC 11021, NSC 40943, NSC 61083
• Empirical Formula (Hill Notation): C₁₃H₉NO
• CAS Number: 1015-89-0
• Molecular Weight: 195.22
• EC Number: 213-804-3
• MDL number: MFCD00004988
• UNSPSC Code: 12352100
• PubChem Substance ID: 24858050
• NACRES: NA.22

Properties

• grade: technical grade
• Quality Level: 100
• form: powder
• mp: 290-292 °C (lit.)
• SMILES string: O=C1Nc2ccccc2-c3ccccc13
• InChI: 1S/C13H9NO/c15-13-11-7-2-1-5-9(11)10-6-3-4-8-12(10)14-13/h1-8H,(H,14,15)
• InChI key: RZFVLEJOHSLEFR-UHFFFAOYSA-N
• Gene Information: human ... PARP1(142)

Description

General description

6-(5H)-Phenanthridinone is an inhibitor of poly(ADP-ribose)polymerase (PARP)-1 activity. The ability of 6-(5H)-phenanthridinone to potentiate the effect of ionizing radiation on tumour cells was evaluated. Action of 6-(5H)-phenanthridinone, one of the most potent PARP inhibitor, on RDM4 murine lymphoma cells in culture was evaluated.

Application

Reactant involved in:

• Synthesis of 5,6-dihydrophenanthridine sulfonamides
• Oxidative coupling with diphenylacetylene
• Direct copper acetate-catalyzed N-cyclopropylation of cyclic amides

Reactant involved in the synthesis and/or pharmacological activity of biologically active molecules including:

• Potassium channel KV1.3 and IK-1 inhibitors
• HIV-1 integrase inhibitors

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves