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805149

Sigma-Aldrich

PLGA nanoparticles

500 nm average diameter

Synonym(s):

Degradex® PLGA, poly(D,L-lactide-co-glycolide)

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About This Item

Linear Formula:
(C3H4O2)x(C2H2O2)y
UNSPSC Code:
12162002
NACRES:
NA.23
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form

powder

Quality Level

average diameter

500 nm

density

1.3 g/cm3

shipped in

wet ice

storage temp.

−20°C

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1 of 4

This Item
PHR1418162341149893
application(s)

liquid formulation
pharma/biopharma processes
pharmaceutical
solid formulation

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care

agency

ChP, NF, JPE

agency

traceable to USP 1623411

agency

-

agency

-

technique(s)

API processing | cocrystal formation: suitable, API processing | salt formation: suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

form

crystalline, solid

form

-

form

crystalline

form

-

assay

99.0-100.5% (HPLC)

assay

-

assay

-

assay

-

density

1.56 g/cm3 at 20 °C

density

-

density

1.564 g/cm3 at 15 °C

density

-

General description

Degradex® is made with poly(D,L-lactide-co-glycolide) with an L/G ratio of 50/50 and a Mw of 30,000.
To re-constitute:
  • Remove the product from freezer.
  • Wait until temperature rises to the ambient temperature.
  • Add DI water or buffer to the container.
  • Vortex and sonicate for 5 minutes to ensure the microspheres are well suspended.

Application

Plain PLGA particles for testing system compatibility in drug delivery research. Particles can be used as carriers by attaching drug or biological/chemical entities to particle surface. PLGA particles are used for controlled release, sustained release and targeted drug delivery.

Legal Information

Degradex is a registered trademark of Phosphorex, Inc.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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