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About This Item
Empirical Formula (Hill Notation):
C28H38N6O11
Molecular Weight:
634.63
UNSPSC Code:
12352200
PubChem Substance ID:
Quality Level
Assay
≥95% (HPLC)
form
lyophilized solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
white
solubility
DMSO: 5 mg/mL
storage temp.
−20°C
SMILES string
CCC(C)C(C(=O)NC(CCC(=O)O)C(=O)N1CCCC1C(=O)NC(CC(=O)O)C(=O)NC2=CC=C(C=C2)[N+](=O)[O-])NC(=O)C
InChI key
YXEIIOVAGGAMCZ-UHFFFAOYSA-N
General description
A colorimetric substrate for granzyme B (kcat/Km = 6.6 x 104 M-1s-1). Cleavage of pNA is monitored colorimetrically at ~405 nm (ε = 9,160 M-1cm-1).
Biochem/physiol Actions
Primary Target
Colorimetric substrate for granzyme B
Colorimetric substrate for granzyme B
kcat/Km = 6.6 x 104 M⁻¹ sec⁻¹ as substrate for granzyme B
Warning
Toxicity: Standard Handling (A)
Sequence
Ac-Ile-Glu-Pro-Asp-pNA
Reconstitution
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Harris, J.L., et al. 1998. J. Biol. Chem. 273, 27364.
Thornberry, N.A., et al. 1997. J. Biol. Chem. 272, 17907.
Thornberry, N.A., et al. 1997. J. Biol. Chem. 272, 17907.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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