46946

Fluorescein isothiocyanate–dextran

average mol wt 150,000, (FITC:Glucose = 1:160)

• Synonym(s): FITC-Dextran 150, FITC–Dextran
• CAS Number: 60842-46-8
• MDL number: MFCD00131092
• UNSPSC Code: 12352201
• NACRES: NA.32

Properties

• form: solid
• Quality Level: 100
• mol wt: average mol wt 150,000
• composition: (FITC:Glucose = 1:160)
• extent of labeling: ~0.004 mol/mol FITC glucose
• solubility: H₂O: 25 mg/mL, slightly hazy, very deep yellow-orange
• fluorescence: λ_ex 492 nm; λ_em 518 nm in 0.1 M phosphate pH 8.0
• storage temp.: 2-8°C

Description

Application

Dextran labeled with fluorescein isothiocyanate for possible use in perfusion studies in animals.

Fluorescein isothiocyanate–dextran (FITC-Dextran 150) is use as a fluorescent probe to study cell permeability. FITC-Dextran 150 is useful to study processes that affect the permeability of the blood brain barrier (BBB) and microvascular structures. FITC-Dextran 150 is used in fluorescence microlymphography.

Other Notes

Commonly utilized as a macromolecular fluorochrome in inflammatory studies

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315 - H319 - H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves