95271

Vitamin K₁

BioXtra, ≥99.0% (sum of isomers, HPLC), mixture of isomers

• Synonym(s): 2-Methyl-3-phytyl-1,4-naphthoquinone, 3-Phytylmenadione, Phylloquinone, Vitamin K₁₍₂₀₎
• Empirical Formula (Hill Notation): C₃₁H₄₆O₂
• CAS Number: 84-80-0
• Molecular Weight: 450.70
• Beilstein: 2568816
• EC Number: 201-564-2
• MDL number: MFCD00214063
• UNSPSC Code: 12352205
• PubChem Substance ID: 57653664
• NACRES: NA.79

Properties

• biological source: synthetic
• Quality Level: 200
• product line: BioXtra
• Assay: ≥99.0% (sum of isomers, HPLC)
• form: viscous liquid
• impurities: ≤20% cis-isomer
• ign. residue: ≤0.1% (as SO₄)
• color: light green-yellow to dark green-yellow; light yellow to dark yellow
• refractive index: n20/D 1.527 (lit.)
• mp: −20 °C (lit.)

Description

General description

Vitamin K₁, also known as phylloquinone, consists of naphthalenoid and phytyl groups.[1] Phylloquinone is present abundantly in photosynthetic plants and is a major dietary source.[2] It is a fat-soluble vitamin.[3]

Application

<ul>
<li><strong>Nutritional strategies for musculoskeletal health:</strong> Nutritional strategies, including Vitamin K1, optimize musculoskeletal health for fall and fracture prevention beyond traditional nutrients like calcium and vitamin D (Webster et al., 2023 doi:10.1016/j.bonr.2023.101684).</li>
<li><strong>Role in coagulation and bone health:</strong> A comprehensive review highlights Vitamin K1′s role in reducing cardiovascular risks and details its biochemical interactions affecting coagulation and bone health (Zhao et al., 2024 doi:10.1017/jns.2023.106).</li>
</ul>

Biochem/physiol Actions

Vitamin K1 (Phylloquinone) is a lipid soluble polycyclic aromatic ketone used as a cofactor in the formation of coagulation factors II (prothrombin), VII, IX and X; anticoagulant factors protein C and S and as a cell signaling factor.

Vitamin K₁ plays a role as a cofactor in the synthesis of γ- carboxy glutamate (Gla), formation of coagulation factors II (prothrombin), VII, IX and X.[4]

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Review: Vitamin K and γ-carboxyglutamate biosynthesis[5]; Metabolic functions and mechanism of action[6]

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves