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B0385

Sigma-Aldrich

Beclomethasone

≥99%

Synonym(s):

9α-Chloro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione, 9α-Chloro-16β-methyl-1,4-pregnadiene-11β,17α,21-triol-3,20-dione

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About This Item

Empirical Formula (Hill Notation):
C22H29ClO5
CAS Number:
4419-39-0
Molecular Weight:
408.92
EC Number:
224-585-9
MDL number:
MFCD00135614
UNSPSC Code:
12352200
PubChem Substance ID:
24278253
NACRES:
NA.77
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Quality Level

100

Assay

≥99%

form

powder

originator

GlaxoSmithKline

storage temp.

2-8°C

SMILES string

[H][C@]12C[C@@H](C)[C@@](O)(C(=O)CO)[C@]1(C)C[C@@H](O)[C@@]3(Cl)[C@]2([H])CCC4=CC(=O)C=C[C@@]34C

InChI

1S/C22H29ClO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12?,15?,16?,17?,19?,20?,21-,22?/m0/s1

InChI key

NBMKJKDGKREAPL-WOOYFSPWSA-N

Gene Information

human ... CYP1A2(1544)

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Show Differences

1 of 4

This Item
B0515B7005D1756
Beclomethasone ≥99%

B0385

Beclomethasone

Betamethasone 17-valerate

B0515

Betamethasone 17-valerate

Betamethasone ≥98%

B7005

Betamethasone

Dexamethasone ≥98% (HPLC), powder

D1756

Dexamethasone

form

powder

form

powder

form

powder

form

powder

assay

≥99%

assay

-

assay

≥98%

assay

≥98% (HPLC)

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

200

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

room temp

storage temp.

2-8°C

originator

GlaxoSmithKline

originator

Schering Plough

originator

-

originator

Merck & Co., Inc., Kenilworth, NJ, U.S.

Gene Information

human ... CYP1A2(1544)

Gene Information

-

Gene Information

human ... ABCB1(5243), CYP3A4(1576), IL4(3565), IL5(3567), NR3C1(2908)
mouse ... Abcb1a(18671), Abcb1b(18669), Ifng(15978), Nos2(18126), Tnf(21926)
rat ... Ar(24208), Nr3c1(24413), Tnf(24835)

Gene Information

human ... ABCB1(5243), CYP3A4(1576), IL4(3565), IL5(3567), NR3C1(2908)
mouse ... Abcb1a(18671), Abcb1b(18669), Ifng(15978), Nos2(18126), Ptgs2(19225), Tnf(21926)
rat ... Ar(24208), Nr3c1(24413), Tnf(24835)

Application

Beclomethasone has been used in MS−MS (mass spectrometry) methods for the analysis of β-agonists, corticosteroids, chloramphenicol and penicillins.[1] It has also been used to find the differential response of glucocorticoids in larval regeneration model.[2]

Biochem/physiol Actions

Beclomethasone is an anti-inflammatory glucocorticoid.
It helps to decrease airway hyperresponsiveness. It also helps to regulate symptoms of asthma.[3]

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves
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    Certificates of Analysis (COA)

    Lot/Batch Number
    MKCQ9505
    MKCN6742
    MKCM3135
    MKCK5840
    MKCF7041

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