C5269

Clindamycin hydrochloride

lincosamide antibiotic

• Synonym(s): (7S)-7-Chloro-7-deoxylincomycin hydrochloride, Cleocin
• Empirical Formula (Hill Notation): C₁₈H₃₃ClN₂O₅S · HCl
• CAS Number: 21462-39-5
• Molecular Weight: 461.44
• Beilstein: 4070786
• MDL number: MFCD07793327
• UNSPSC Code: 51102829
• PubChem Substance ID: 24892772
• NACRES: NA.85

Properties

• Quality Level: 200
• form: powder or crystals
• impurities: ≤13%
• solubility: H₂O: 50 mg/mL
• antibiotic activity spectrum: Gram-negative bacteria; Gram-positive bacteria
• Mode of action: protein synthesis | interferes
• storage temp.: 2-8°C
• SMILES string: Cl.CCC[C@@H]1C[C@H](N(C)C1)C(=O)N[C@H]([C@H](C)Cl)C2O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O
• InChI: 1S/C18H33ClN2O5S.ClH/c1-5-6-10-7-11(21(3)8-10)17(25)20-12(9(2)19)16-14(23)13(22)15(24)18(26-16)27-4;/h9-16,18,22-24H,5-8H2,1-4H3,(H,20,25);1H/t9-,10+,11-,12+,13-,14+,15+,16+,18+;/m0./s1
• InChI key: AUODDLQVRAJAJM-XJQDNNTCSA-N

Description

General description

Chemical structure: macrolide

Application

Clindamycin is used to study bacterial infections, such as group B streptococcal disease, bacterial resistance and plasma protein binding.

Used to study bacterial protein synthesis.

Biochem/physiol Actions

Clindamycin hydrochloride is highly effective against anaerobic species.

Clindamycin is a semi-synthetic, lincosamide antibiotic that is prepared from lincomycin. It inhibits bacterial protein synthesis by hydrogen bond interactions with the 23S rRNA component of the 50S ribosomal subunit thus inducing dissociation of the peptidyl-t-RNA complex. It has antibacterial activity against Gram-positive cocci and antiprotozoal activity against Taxoplasma.

Other Notes

Antibacterial and antiprotozoal antibiotic of the lincosamide class.

Keep container tightly closed in a dry and well-ventilated place.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H317,H319,H362
• Precautionary Statements: P260 - P263 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Eye Irrit. 2 - Lact. - Skin Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable