D0540

DNQX

≥98% (TLC)

• Synonym(s): 6,7-Dinitroquinoxaline-2,3(1H,4H)-dione
• Empirical Formula (Hill Notation): C₈H₄N₄O₆
• CAS Number: 2379-57-9
• Molecular Weight: 252.14
• MDL number: MFCD00069257
• UNSPSC Code: 51111800
• PubChem Substance ID: 24277973
• NACRES: NA.77

Properties

• Quality Level: 200
• Assay: ≥98% (TLC)
• form: powder
• SMILES string: [O-][N+](=O)c1cc2NC(=O)C(=O)Nc2cc1[N+]([O-])=O
• InChI: 1S/C8H4N4O6/c13-7-8(14)10-4-2-6(12(17)18)5(11(15)16)1-3(4)9-7/h1-2H,(H,9,13)(H,10,14)
• InChI key: RWVIMCIPOAXUDG-UHFFFAOYSA-N
• Gene Information: human ... GRIA1(2890), GRIA2(2891), GRIK1(2897), GRIK2(2898), GRIK3(2899), GRIK4(2900), GRIK5(2901) ; mouse ... Gria1(14799) ; rat ... Gria1(50592), Grik1(29559), Grik4(24406), Grin2a(24409)

Description

Application

DNQX has been used to block N-Methyl-D-aspartic acid (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in various experiments.

Biochem/physiol Actions

A competitive kainate, quisqualate (non-NMDA) glutamate receptor antagonist.

DNQX is a quinoxaline derivative.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.