G7504

Guanosine 3′,5′-cyclic monophosphate

≥98% (HPLC), powder, intracellular mediator

• Synonym(s): cGMP, cyclic GMP
• Empirical Formula (Hill Notation): C₁₀H₁₂N₅O₇P
• CAS Number: 7665-99-8
• Molecular Weight: 345.21
• EC Number: 231-641-6
• MDL number: MFCD00070129
• UNSPSC Code: 41106305
• PubChem Substance ID: 24895309
• NACRES: NA.77

Properties

• Product Name: Guanosine 3′,5′-cyclic monophosphate, ≥98% (HPLC), powder
• Quality Level: 200
• Assay: ≥98% (HPLC)
• form: powder
• color: white
• solubility: 0.2 M NaHCO₃: 50 mg/mL
• storage temp.: −20°C
• SMILES string: NC1=NC(=O)c2ncn(C3OC4COP(O)(=O)OC4C3O)c2N1
• InChI: 1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)
• InChI key: ZOOGRGPOEVQQDX-UHFFFAOYSA-N

Description

Biochem/physiol Actions

An important second messenger, cGMP is a major intracellular mediator of extracellular signals such as nitric oxide and natriuretic peptides. Cyclic GMP interacts with three types of intracellular receptor proteins: cGMP-dependent protein kinases, cGMP-regulated channels, and cGMP-regulated cyclic nucleotide phosphodiesterases. A primary action of elevated cGMP levels in vivo is the stimulation of cGMP-dependent protein kinase (PKG).

Features and Benefits

This compound is a featured product for ADME Tox and Cyclic Nucleotide research. Discover more featured ADME Tox and Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves