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HUMANPBMC-0002196

Sigma-Aldrich

Frozen Human Psoriasis PBMC

human peripheral blood (mononuclear cells)

Synonym(s):

Immune Cells, Peripheral Blood Mononuclear Cells, Psoriasis PBMC

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UNSPSC Code:
41106514
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Product Name

Frozen Human Psoriasis PBMC, 20 Million Cells/per vial

biological source

human peripheral blood (mononuclear cells)

Quality Level

100

form

frozen liquid

packaging

vial of 20 Million cells

manufacturer/tradename

BioIVT

technique(s)

cell culture | mammalian: suitable

color

cloudy

storage temp.

-140 to -196°C

General description

Lot specific orders are not able to be placed through the web. Contact your local sales rep for more details.

We are pleased to offer these products from BioIVT.

Offering isolated Peripheral Blood Mononuclear Cells (PBMCs) from whole blood procured from IRB-consented donors with clinically defined Psoriasis.

Peripheral Blood Mononuclear Cells (PBMCs) are a subset of leukocytes (or White Blood Cell, WBC), which are integral components of the body′s immune system that fight disease. PBMCs consist of a mixture of lymphocytes (T cells, B cells, and NK cells) and monocytes and are isolated from peripheral whole blood via density gradient centrifugation and red blood cell lysis.

Standard and custom clinical data collection and confirmation ensures proper corresponding disease severity and treatment history.

Included Diagnoses: Plaque Psoriasis, Inverse Psoriasis, Erythrodermic Psoriasis, Psoriasis Vulgaris, Pustular Psoriasis

Clinical data may include: Medication (current and historical), Disease severity, PASI Score, BSA, HLA

PBMCs are provided with clinical data that has been collected following a strict and standardized clinical data process. All specimens are reviewed for IRB approval.

Packaging

20 Million Cells/per vial

Other Notes

Thaw before use.

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Pictograms

Corrosion
GHS05

Signal Word

Warning

Hazard Statements

H290,H315,H319

Hazard Classifications

Eye Irrit. 2 - Met. Corr. 1 - Skin Irrit. 2

Storage Class Code

8B - Non-combustible corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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    Kazuhisa Nakano et al.
    Journal of immunology (Baltimore, Md. : 1950), 190(3), 1297-1303 (2013-01-02)
    Rheumatoid arthritis (RA) is a chronic inflammatory disease in which fibroblast-like synoviocytes (FLS) exhibit an aggressive phenotype. Although the mechanisms responsible are not well defined, epigenetic determinants such as DNA methylation might contribute. DNA methyltransferases (DNMTs) are critical enzymes that
    Vitalina M Komashko et al.
    Epigenetics, 5(3), 229-240 (2010-03-23)
    Methylation of DNA in combination with histone modifications establishes an epigenetic code that ensures the proper control of gene expression. Although DNA methyltransferases have been shown to interact with histone methyltransferases such as EZH2 (which methylates histone H3 on lysine
    INSIG2 rs7566605 single nucleotide variant and global DNA methylation index levels are associated with weight loss in a personalized weight reduction program
    Pirini F, et al.
    Molecular Medicine Reports, 17(1), 1699-1709 (2018)
    Rafael Guerrero-Preston et al.
    Epigenetics, 5(6), 539-546 (2010-06-05)
    Environmental exposures in-utero may alter the epigenome, thus impacting chromosomal stability and gene expression. We hypothesized that in utero exposures to maternal smoking and perfluoroalkyl compounds (PFCs) are associated with global DNA hypomethylation in umbilical cord serum. Our objective was
    Magdalena Gryzinska et al.
    Biochemical genetics, 51(7-8), 554-563 (2013-04-05)
    DNA methylation is an epigenetic modification that plays an important role in the normal development and function of organisms. The level of DNA methylation is species-, tissue-, and organelle-specific, and the methylation pattern is determined during embryogenesis. DNA methylation has
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