K1639
K-252a
from Nonomuraea longicatena, ≥98% (HPLC)
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About This Item
Empirical Formula (Hill Notation):
C27H21N3O5
CAS Number:
Molecular Weight:
467.47
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
biological source
Nonomuraea longicatena
Quality Level
Assay
≥98% (HPLC)
form
solid
solubility
DMF: 1 mg/mL
DMSO: 1 mg/mL
antibiotic activity spectrum
viruses
Mode of action
enzyme | inhibits
shipped in
dry ice
storage temp.
−20°C
SMILES string
[H][C@]12C[C@](O)(C(=O)OC)[C@](C)(O1)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35
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Application
K-252a has been used:
- as a tropomyosin receptor kinase (Trk) inhibitor to study the role of TrkA signaling in rats
- as a Trk inhibitor for inducing in vitro injury in retinal Müller glial cells to study the effects of cord blood serum (CBS)
- as a general protein kinase inhibitor to study its effect on in vitro human somatic testicular cell reassembly
Biochem/physiol Actions
K-252a is a selective inhibitor of tyrosine protein kinase. It targets a wide range of protein kinases with IC50 values between 3 and 25nM and the neurotrophin receptor-tropomyosin receptor kinase.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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