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About This Item
Empirical Formula (Hill Notation):
C12H21N · HCl
CAS Number:
Molecular Weight:
215.76
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Product Name
Memantine hydrochloride, ≥98% (GC)
Quality Level
Assay
≥98% (GC)
form
powder
originator
Forest Labs
SMILES string
Cl.C[C@]12CC3C[C@](C)(C1)CC(N)(C3)C2
InChI
1S/C12H21N.ClH/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10;/h9H,3-8,13H2,1-2H3;1H/t9-,10+,11-,12-;
InChI key
LDDHMLJTFXJGPI-VXMZOEJHSA-N
Gene Information
human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816)
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Application
Memantine hydrochloride has been used:
- as a media supplement to serve as a control to study the neuroprotective effects of erythropoietin in N-methyl-D-aspartate receptor-induced toxicity
- to intraperitoneally inject experimental animal to study its effect on traumatic injury
- as a test compound to determine the dynamic range and selectivity of retinal pigment epithelium tissue penetration
Biochem/physiol Actions
Low-affinity NMDA glutamate receptor antagonist; stimulates dopamine release.
Memantine is effective against Alzheimer′s disease and Parkinson′s disease. It is also useful in treating epilepsy, motor neurone disease and trauma.
Features and Benefits
This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Forest Labs. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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