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PZ0112

Sigma-Aldrich

PD-184161

≥98% (HPLC)

Synonym(s):

5-Bromo-2-[(2-chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluoro-benzamide, PF-1529483, PF-3011370, UK-287074

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5 ML
CA$183.00
50 ML
CA$1,080.00

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5 ML
CA$183.00
50 ML
CA$1,080.00

About This Item

Empirical Formula (Hill Notation):
C17H13BrClF2IN2O2
CAS Number:
Molecular Weight:
557.56
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

CA$183.00


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Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: >10 mg/mL

storage temp.

2-8°C

SMILES string

Fc1c(F)c(Nc2ccc(I)cc2Cl)c(cc1Br)C(=O)NOCC3CC3

InChI

1S/C17H13BrClF2IN2O2/c18-11-6-10(17(25)24-26-7-8-1-2-8)16(15(21)14(11)20)23-13-4-3-9(22)5-12(13)19/h3-6,8,23H,1-2,7H2,(H,24,25)

InChI key

VJNZMSLGVUSPCF-UHFFFAOYSA-N

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This Item
Z334324Z334316Z334243
material

polypropylene

material

polypropylene

material

polypropylene

material

polypropylene

manufacturer/tradename

BRAND 4340012

manufacturer/tradename

BRAND 4340010

manufacturer/tradename

BRAND 4340060

manufacturer/tradename

BRAND 4340062

feature

autoclavable at 121°C (2 bar), acc to DIN EN 258, Holds 55 x 18 mm tubes, positions 5 × 11

feature

autoclavable at 121°C (2 bar), acc to DIN EN 258, positions 5 × 11, Holds 55 x 18 mm tubes

feature

autoclavable at 121°C (2 bar), acc to DIN EN 258, positions 5 × 11, Holds 55 x 16 mm tubes

feature

autoclavable at 121°C (2 bar), acc to DIN EN 258, positions 5 × 11, Holds 55 x 16 mm tubes

L × W × H

265 mm × 126 mm × 75 mm

L × W × H

265 mm × 126 mm × 75 mm

L × W × H

265 mm × 126 mm × 75 mm

L × W × H

265 mm × 126 mm × 75 mm

color

red

color

white

color

white

color

red

Biochem/physiol Actions

PD-184161 is a MEK inhibitor.

Features and Benefits

This compound is featured on the MAPKKKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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T Furuzono et al.
Biomaterials, 21(4), 327-333 (2000-02-03)
2-Methacryloyloxyethyl phosphorylcholine (MPC) was grafted onto silk fabric in a two-step heterogeneous system through the vinyl bonds of 2-methacryloyloxyethyl isocyanate (MOI) modified on the fabric. First, habutae silk fabric was modified with the MOI monomer in anhydrous dimethyl sulfoxide using
Spec. Chem. Technol., 29, 765-765 (1984)
Christine Lehmann et al.
PLoS pathogens, 14(5), e1007031-e1007031 (2018-05-17)
Parasite egress from infected erythrocytes and invasion of new red blood cells are essential processes for the exponential asexual replication of the malaria parasite. These two tightly coordinated events take place in less than a minute and are in part
T Konno et al.
Biomaterials, 22(13), 1883-1889 (2001-06-09)
The poly(L-lactic acid) nanoparticles immobilized with 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer, which has excellent blood compatibility, were prepared by a solvent evaporation technique using the water-soluble amphiphilic MPC polymer as an emulsifier and a surface modifier. The diameter and zeta-potential of
Mitsumasa Sudo et al.
Atherosclerosis, 265, 283-291 (2017-07-12)
Glucagon-like peptide-1 (GLP-1) is thought to inhibit development of aortic atherosclerosis and plaque formation. However, whether GLP-1 stabilizes fully developed atherosclerotic plaque or alters the complicated plaque composition remains unclarified. Ten Watanabe heritable hyperlipidemic (WHHL) rabbits were divided into GLP-1

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