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SAB5700256

Sigma-Aldrich

Anti-SMAD2 antibody produced in rabbit

Synonym(s):

JV18, JV18-1, MADH2, MADR2, SMAD2, Smad2, hMAD-2, hSMAD2

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
Pricing and availability is not currently available.
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biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

48
 52

species reactivity

human, mouse, rat

concentration

0.94 mg/ml

technique(s)

immunofluorescence: 1:50-1:200
immunohistochemistry: 1:50-1:200
western blot: 1:500-1:2000

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This Item
Y0000887Y0000679C3090000
1-Methylpiperazine European Pharmacopoeia (EP) Reference Standard

Y0000886

1-Methylpiperazine

Cyclizine impurity B European Pharmacopoeia (EP) Reference Standard

Y0000887

Cyclizine impurity B

vibrant-m

Y0000679

Mepyramine impurity A

vibrant-m

C3090000

Cyclizine hydrochloride

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

manufacturer/tradename

EDQM

manufacturer/tradename

EDQM

manufacturer/tradename

EDQM

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

format

neat

format

neat

format

neat

format

neat

vapor density

3.5 (vs air)

vapor density

-

vapor density

-

vapor density

-

API family

cyclizine

API family

cyclizine

API family

pyrilamine, mepyramine

API family

cyclizine

General description

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene ′mothers against decapentaplegic′ (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene.

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SMAD2 (NP_001003652.1).

Physical form

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Storage and Stability

Store at -20℃. Avoid freeze / thaw cycles.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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