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SML0005

Sigma-Aldrich

Cerivastatin sodium salt hydrate

≥98% (HPLC)

Synonym(s):

(3R,5S,6E)-7-[4-(4-Fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl]-3,5-dihydroxy-6-heptenoic acid sodium salt hydrate, Rivastatin hydrate

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30 X 30 ML
192,00 $
4 L
280,00 $

192,00 $

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30 X 30 ML
192,00 $
4 L
280,00 $

About This Item

Empirical Formula (Hill Notation):
C26H33FNNaO5 · xH2O
CAS Number:
143201-11-0
Molecular Weight:
481.53 (anhydrous basis)
MDL number:
MFCD20488047
UNSPSC Code:
12352200
PubChem Substance ID:
329825082
NACRES:
NA.77

192,00 $

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Quality Level

100

Assay

≥98% (HPLC)

form

powder

optical activity

[α]/D +18 to +26° in ethanol

storage condition

desiccated

color

white to tan

solubility

H2O: ≥5 mg/mL

originator

Bayer

storage temp.

2-8°C

SMILES string

O.[Na+].COCc1c(nc(C(C)C)c(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)c1-c2ccc(F)cc2)C(C)C

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application(s)

environmental
food and beverages
general analytical
industrial qc
pharmaceutical

application(s)

environmental
food and beverages
general analytical
industrial qc
pharmaceutical

application(s)

environmental
food and beverages
general analytical
industrial qc
pharmaceutical

application(s)

environmental
food and beverages
general analytical
industrial qc
pharmaceutical

pH

12.0 (25 °C in H2O)

pH

11.0 (25 °C in H2O)

pH

2.0 (25 °C in H2O)

pH

1.0 (25 °C in H2O)

density

1.00 g/cm3 at 20 °C

density

1.01 g/cm3 at 20 °C

density

1.00 g/cm3 at 20 °C

density

1.00 g/cm3 at 20 °C

General description

Cerivastatin sodium salt hydrate belongs to the statin class of lipid lowering agents.[1] It helps in decreasing MAP kinase activation, blocking AP-1 (activator protein-1) and NF-kB (nuclear factor-kB ) binding activity, inhibiting inflammatory responses and ameliorated renal damage. It also lowers cholesterol.[2] It is metabolized by cytochrome P450 (CYP)3A4 and (CYP)2C8.[1] Cerivastatin sodium salt hydrate is linked to rhabdomyolysis.[3]

Application

Cerivastatin sodium salt hydrate has been used as a supplement in cell culture.[4]
Cerivastatin sodium salt hydrate may be used in cell signaling studies.

Biochem/physiol Actions

Accumulated macrophages in atherosclerotic plaques result in plaque rupture and thrombus formation. Cerivastatin suppresses the growth of macrophages and decreases the expression of matrix metalloproteinases and tissue factor molecules, thus reduces acute coronary events.[5][6]
Cerivastatin sodium is an HMG-CoA reductase inhibitor. HMG-CoA is a key enzyme in the production of cholesterol.
HMG-CoA reductase inhibitor

Features and Benefits

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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    Certificates of Analysis (COA)

    Lot/Batch Number
    124M4714V
    014M4703V
    071M4723V

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