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SML0971

Sigma-Aldrich

Ki 16425

≥98% (HPLC)

Synonym(s):

3-[[[4-[4-[[[1-(2-Chlorophenyl)ethoxy]carbonyl]amino]-3-methyl-5-isoxazolyl]phenyl]methyl]thio]-propanoic acid, Ki16425

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100 μL
CA$440.00

CA$440.00


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100 μL
CA$440.00

About This Item

Empirical Formula (Hill Notation):
C23H23ClN2O5S
CAS Number:
Molecular Weight:
474.96
UNSPSC Code:
12352200
NACRES:
NA.77

CA$440.00


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Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

−20°C

SMILES string

S(CCC(=O)O)Cc1ccc(cc1)c2[o]nc(c2NC(=O)OC(C)c3c(cccc3)Cl)C

InChI

1S/C23H23ClN2O5S/c1-14-21(25-23(29)30-15(2)18-5-3-4-6-19(18)24)22(31-26-14)17-9-7-16(8-10-17)13-32-12-11-20(27)28/h3-10,15H,11-13H2,1-2H3,(H,25,29)(H,27,28)

InChI key

LLIFMNUXGDHTRO-UHFFFAOYSA-N

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Show Differences

1 of 4

This Item
SAB5700636N7782MABN527
biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

mouse

clone

SP126, monoclonal

clone

polyclonal

clone

polyclonal

clone

13F5.1, monoclonal

conjugate

unconjugated

conjugate

-

conjugate

unconjugated

conjugate

-

Gene Information

human ... NOS2(4843)

Gene Information

human ... NOS2(4843)

Gene Information

mouse ... Nos2(18126)
rat ... Nos2(24599)

Gene Information

human ... NOS2(4843)

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

IgG fraction of antiserum

antibody form

culture supernatant

species reactivity

human (tested)

species reactivity

rat, mouse

species reactivity

rat, mouse

species reactivity

human

Application

Ki 16425 has been used as a chemical inhibitor to study the regulation of LPA (lysophosphatidic acid) on LPAR(LPA receptor) subtypes.[1]

Biochem/physiol Actions

Ki 16425 possesses a short-lived inhibitory activity. It has been studied that Ki 16425 is effective in the inhibition of neuropathic pain‐like behaviors.[2]
Ki16452 is a potent antagonist of the lysophosphatidic acid receptors LPA1 and LPA3, with greater than 30-fold selectivity for LPA1 over LPA2. The Ki values for LPA1 and LPA3 are 250 nM and 360 nM, respectively.
Ki16452 is a potent antagonist of the lysophosphatidic acid receptors LPA1 and LPA3.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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