SML1448

Cycloastragenol

≥98% (HPLC)

• Synonym(s): Astramembrangenin, Cyclosieversigenin, Cyclosiversigenin, GRN510, TAT2, (3β,6α,16β,20R,24S)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol, Cyclogalegigenin
• Empirical Formula (Hill Notation): C₃₀H₅₀O₅
• CAS Number: 78574-94-4
• Molecular Weight: 490.72
• MDL number: MFCD24849201
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825888
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D +45 to +60°, c = 1 in methanol
• color: white to beige
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: C[C@]1(O[C@H](C(O)(C)C)CC1)[C@@]2([H])[C@@H](O)C[C@@]3(C)[C@]4([H])C[C@H](O)[C@@]5([H])C(C)(C)[C@@H](O)CC[C@]5(C6)[C@]46CC[C@@]32C
• InChI: 1S/C30H50O5/c1-24(2)20(33)8-11-30-16-29(30)13-12-26(5)23(28(7)10-9-21(35-28)25(3,4)34)18(32)15-27(26,6)19(29)14-17(31)22(24)30/h17-23,31-34H,8-16H2,1-7H3/t17-,18-,19-,20-,21-,22-,23-,26+,27-,28+,29-,30+/m0/s1
• InChI key: WENNXORDXYGDTP-UOUCMYEWSA-N

Description

General description

Cycloastragenol is isolated from Astragalus species.

Biochem/physiol Actions

Cycloastragenol is an aglycone of astragaloside IV isolated from Astragalus species that exhibits anti-inflammatory properties and promotes and wound gap closure. Cycloastragenol enhances the antiviral response in human CD8+ T-lymphocytes. Cycloastragenol induces telomerase activity and induces CREB (cAMP response element binding) activation in human neonatal keratinocytes, PC12 cells, and primary neurons.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable