Name: Idalopirdine
Brand: SIGMA

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₁₉F₅N₂O

CAS Number:

467459-31-0

Molecular Weight:

398.37

MDL number:

MFCD18633269

UNSPSC Code:

51111800

NACRES:

NA.77

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Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

SMILES string

FC(F)(C(F)F)COc1cc(ccc1)CNCCc2c3c([nH]c2)cc(cc3)F

InChI

1S/C20H19F5N2O/c21-15-4-5-17-14(11-27-18(17)9-15)6-7-26-10-13-2-1-3-16(8-13)28-12-20(24,25)19(22)23/h1-5,8-9,11,19,26-27H,6-7,10,12H2

InChI key

YBAWYTYNMZWMMJ-UHFFFAOYSA-N

Biochem/physiol Actions

Idalopirdine (Lu AE58054) is an orally available, and potent antagonist of the serotonin 6 (5-HT6) receptor. Idalopirdine has been reported to be highly selective over other G-protein coupled receptors. It has K(d) of 0.2nM for the 5-HT6 receptor with 16-fold selectivity over the 5-HT2A receptor (K(i) 3.2nM) and >100-fold selectivity to all other evaluated targets.

Orally available, selective and potent antagonist of the serotonin 6 (5-HT6) receptor.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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