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About This Item
Empirical Formula (Hill Notation):
C48H55N11O8
CAS Number:
Molecular Weight:
914.02
UNSPSC Code:
12352200
NACRES:
NA.77
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (Warmed)
storage temp.
2-8°C
SMILES string
O=C(NCC1=C(C=C(NC1=O)C)C)C2=CC(C3=CC=C(N=C3)N4CCN(CC4)CCNC(CCOCCNC5=CC=CC(C(N6C(C(N7)=O)CCC7=O)=O)=C5C6=O)=O)=CC8=C2C=NN8C(C)C
Biochem/physiol Actions
Cell penetrant and potent PROTAC degrader of EZH2 that effectively depletes both canonical EZH2–PRC2 and noncanonical EZH2–cMyc complexes
MS177 is a cell penetrant and potent PROTAC degrader of EZH2 (enhancer of zeste homologue 2) that effectively depletes both canonical EZH2–PRC2 and noncanonical EZH2–cMyc complexes. MS177 is fast-acting suppressor of cancer growth. MS177 comprises pomalidomide conjugated to a potent EZH2 inhibitor C24 via a short polyethylene glycol linker. It is much more effective and potent in suppressing cancer growth than catalytic inhibitors of EZH2.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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