466964

4′-Fluoro-2′-hydroxyacetophenone

98%

• Formule linéaire : FC₆H₃(OH)COCH₃
• CAS Number: 1481-27-2
• Poids moléculaire : 154.14
• Numéro MDL: MFCD00143203
• Code UNSPSC : 12352100
• ID de substance PubChem : 24870373
• Nomenclature NACRES : NA.22

Propriétés

• Niveau de qualité: 100
• Essai: 98%
• Pf: 31-35 °C (lit.)
• Groupe fonctionnel: fluoro; ketone
• Chaîne SMILES: CC(=O)c1ccc(F)cc1O
• InChI: 1S/C8H7FO2/c1-5(10)7-3-2-6(9)4-8(7)11/h2-4,11H,1H3
• Clé InChI: HLTBTUXAMVOKIH-UHFFFAOYSA-N

Description

Description générale

4′-Fluoro-2′-hydroxyacetophenone is a substituted acetophenone derivative. Biological Baeyer-Villiger oxidation of 4′-fluoro-2′-hydroxyacetophenone to 4-fluorocatechol by using whole cells of Pseudomonas fluorescens ACB has been reported. Its crystals belong to the monoclinic crystal system and space group P2₁/n.

Application

4′-Fluoro-2′-hydroxyacetophenone may be used in the preparation of series of 4′-fluoro-2′-hydroxychalcones, via aldol condensation with substituted aldehydes followed by cyclization with hydrazine hydrate.

Used recently in the preparation of medicinally active benzo[b]furans and thiophenes.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H315,H319,H335
• Conseils de prudence: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): 210.2 °F - closed cup
• Point d'éclair (°C): 99 °C - closed cup
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves