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QBD10314

Sigma-Aldrich

MAL-dPEG®24-NHS ester

Synonyme(s) :

Polyethylene glycol

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About This Item

Formule empirique (notation de Hill) :
C62H111N3O31
Poids moléculaire :
1394.55
Numéro MDL:
MFCD11041160
Code UNSPSC :
12352108
ID de substance PubChem :
329823914
Nomenclature NACRES :
NA.22
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Essai

>90%

Forme

solid or viscous liquid

Pertinence de la réaction

reactivity: thiol reactive
reagent type: cross-linking reagent
reactivity: amine reactive

Architecture des polymères

shape: linear
functionality: heterobifunctional

Conditions d'expédition

ambient

Température de stockage

−20°C

Chaîne SMILES 

O=C(NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O)CCN2C(C=CC2=O)=O

InChI

1S/C62H111N3O31/c66-57(5-8-64-58(67)1-2-59(64)68)63-7-10-73-12-14-75-16-18-77-20-22-79-24-26-81-28-30-83-32-34-85-36-38-87-40-42-89-44-46-91-48-50-93-52-54-95-56-55-94-53-51-92-49-47-90-45-43-88-41-39-86-37-35-84-33-31-82-29-27-80-25-23-78-21-19-76-17-15-

Clé InChI

GRDUWUCYIIEBIS-UHFFFAOYSA-N

Catégories apparentées

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Cet article
53557-U53559-U53560-U
Ascentis® Express 90 Å PFAS, 2.7 μm HPLC Column suitable for PFAS testing, column L × I.D. 25 cm × 3.0 mm

53570-U

Ascentis® Express 90 Å PFAS, 2.7 μm HPLC Column

Ascentis® Express 90 Å PFAS, 2.7 μm HPLC Column suitable for PFAS testing, column L × I.D. 5 cm × 2.1 mm

53557-U

Ascentis® Express 90 Å PFAS, 2.7 μm HPLC Column

Ascentis® Express 90 Å PFAS, 2.7 μm HPLC Column column L × I.D. 10 cm × 2.1 mm, suitable for PFAS testing

53559-U

Ascentis® Express 90 Å PFAS, 2.7 μm HPLC Column

Ascentis® Express 90 Å PFAS, 2.7 μm HPLC Column suitable for PFAS testing, column L × I.D. 15 cm × 2.1 mm

53560-U

Ascentis® Express 90 Å PFAS, 2.7 μm HPLC Column

particle size

2.7 μm

particle size

2.7 μm

particle size

2.7 μm

particle size

2.7 μm

separation technique

reversed phase

separation technique

reversed phase

separation technique

reversed phase

separation technique

reversed phase

matrix active group

C18, extensively endcapped octadecylsilane (ODS) bonding phase

matrix active group

C18, extensively endcapped octadecylsilane (ODS) bonding phase

matrix active group

C18, extensively endcapped octadecylsilane (ODS) bonding phase

matrix active group

C18, extensively endcapped octadecylsilane (ODS) bonding phase

agency

suitable for ASTM® 7968, suitable for DIN 38407-42, suitable for EPA 537.1, suitable for EPA ACB B21-02, suitable for EPA OTM-45, suitable for ISO 21675 2019, suitable for ISO/CEN 15968-2010, suitable for ASTM® 7979, suitable for EPA 8327, suitable for GB 5009.253-2016, suitable for USP L1, suitable for EPA 533, suitable for ISO 25101, suitable for EPA ACB B23-05b

agency

suitable for ASTM® 7968, suitable for ASTM® 7979, suitable for DIN 38407-42, suitable for EPA 533, suitable for EPA 537.1, suitable for EPA 8327, suitable for EPA ACB B21-02, suitable for EPA ACB B23-05b, suitable for EPA OTM-45, suitable for GB 5009.253-2016, suitable for ISO 21675 2019, suitable for ISO 25101, suitable for ISO/CEN 15968-2010, suitable for USP L1

agency

suitable for ASTM® 7968, suitable for ASTM® 7979, suitable for DIN 38407-42, suitable for EPA 533, suitable for EPA 537.1, suitable for EPA 8327, suitable for EPA ACB B21-02, suitable for EPA ACB B23-05b, suitable for EPA OTM-45, suitable for GB 5009.253-2016, suitable for ISO 21675 2019, suitable for ISO 25101, suitable for ISO/CEN 15968-2010, suitable for USP L1

agency

suitable for ASTM® 7968, suitable for ASTM® 7979, suitable for DIN 38407-42, suitable for EPA 533, suitable for EPA 537.1, suitable for EPA 8327, suitable for EPA ACB B21-02, suitable for EPA ACB B23-05b, suitable for EPA OTM-45, suitable for GB 31604.35-2016, suitable for GB 5009.253-2016, suitable for ISO 21675 2019, suitable for ISO 25101, suitable for ISO/CEN 15968-2010, suitable for USP L1

technique(s)

HPLC: suitable, LC/MS: suitable

technique(s)

HPLC: suitable, LC/MS: suitable, UHPLC-MS: suitable, UHPLC: suitable

technique(s)

HPLC: suitable, LC/MS: suitable, UHPLC-MS: suitable, UHPLC: suitable

technique(s)

HPLC: suitable, LC/MS: suitable, UHPLC-MS: suitable, UHPLC: suitable

pore size

90 Å pore size

pore size

90 Å pore size

pore size

90 Å pore size

pore size

90 Å pore size

Caractéristiques et avantages

MAL-dPEG® 24-NHS ester is a heterobifunctional, linear crosslinking reagents containing a maleimide group on one end of the single molecular weight dPEG® spacer arm and an amine-reactive active ester on the other end. The number following the dPEG® refers to the exact number of spacer units present in the spacer arm. The maleimide group reacts readily and specifically with free sulfhydryl groups in aqueous media at pH 6.5-7.5. N-hydroxysuccinimide (NHS) ester are used widely in reactions with primary amines. The NHS-amine reactions can be carried out in aqueous or organic solvent. The dPEG® spacer is hydrophilic and non-immunogenic. Because it is a single molecular weight product, it gives the user precise spatial control. The dPEG® spacer also improves water solubility, decreases immunogenicity, and increases the hydrodynamic volume of the conjugate. The increased hydrodynamic volume results in longer serum half-life in vivo.

Informations légales

Products Protected under U.S. Patents # 7,888,536 B2
dPEG is a registered trademark of Quanta BioDesign

Code de la classe de stockage

11 - Combustible Solids

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Hongmei Li et al.
Nature cell biology, 15(7), 773-785 (2013-06-25)
Following exocytosis, the rate of recovery of neurotransmitter release is determined by vesicle retrieval from the plasma membrane and by recruitment of vesicles from reserve pools within the synapse, which is dependent on mitochondrial ATP. The anti-apoptotic Bcl-2 family protein
Hala Guedouari et al.
Biochimica et biophysica acta. Molecular cell research, 1864(1), 169-176 (2017-03-28)
During starvation, intra-mitochondrial sirtuins, NAD+ sensitive deacylating enzymes that modulate metabolic homeostasis and survival, directly adjust mitochondrial function to nutrient availability; concomitantly, mitochondria elongate to escape autophagic degradation. However, whether sirtuins also impinge on mitochondrial dynamics is still uncharacterized. Here
Shilpa Gandre-Babbe et al.
Molecular biology of the cell, 19(6), 2402-2412 (2008-03-21)
Few components of the mitochondrial fission machinery are known, even though mitochondrial fission is a complex process of vital importance for cell growth and survival. Here, we describe a novel protein that controls mitochondrial fission. This protein was identified in
Sebastian Carsten Johannes Helle et al.
eLife, 6 (2017-11-10)
Eukaryotic cells are densely packed with macromolecular complexes and intertwining organelles, continually transported and reshaped. Intriguingly, organelles avoid clashing and entangling with each other in such limited space. Mitochondria form extensive networks constantly remodeled by fission and fusion. Here, we
Carmela Guido et al.
Oncotarget, 3(8), 798-810 (2012-08-11)
Recent studies have suggested that cancer cells behave as metabolic parasites, by inducing oxidative stress in adjacent normal fibroblasts. More specifically, oncogenic mutations in cancer cells lead to ROS production and the "secretion" of hydrogen peroxide species. Oxidative stress in
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