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About This Item

Code UNSPSC :
41116107
Nomenclature NACRES :
NA.24
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Qualité

certified reference material

Niveau de qualité

Forme

liquid

Conditionnement

pkg of 4 x 1 mL

Fabricant/nom de marque

NIST®

Technique(s)

mass spectrometry (MS): suitable

Application(s)

clinical testing

Format

matrix material

Description générale

Determining total 25-hydroxy vitamin D [25(OH)D] concentration in serum, the sum of 25-hydroxyvitamin D2 [25(OH)D2] and 25-hydroxyvitamin D3 [25(OH)D3] is generally considered a reliable indicator of vitamin D status. Measurement of 24R, 25(OH)2D3 in serum is considered a catabolism marker and an indicator of kidney disease. A unit of SRM 972a contains 1 mL of four vials (levels 1 through 4) of frozen serum with different concentration levels of 25-hydroxyvitamin D [25(OH)D] and 24R, 25-dihydroxy vitamin D3 [24R,25(OH)2D3].

NIST972A_Cert

NIST972A_SDS

Application

This vitamin D metabolite standard reference material (SRM) is intended for use as an accuracy control in the evaluation of methods for determining the amount-of-substance concentration of vitamin D metabolites in human serum. This SRM can also be used as a quality assurance tool for assigning values to in-house control materials for these constituents.
Vitamin D metabolites in frozen human serum has been used as a reference material for the calibration and standardization of 25-hydroxyvitamin D (25(OH)D) from dried blood spot samples by liquid chromatography-tandem mass spectrometry (LC-MS/MS).

Actions biochimiques/physiologiques

Vitamin D known as cholecalciferol exists as vitamin D3. It is taken in the diet through fortified dairy products and fish oils. It is synthesized in the skin from 7-dehydrocholesterol by ultraviolet irradiation. The biologically active form of vitamin D, 25(OH)2D3, is essential for mineral metabolism, and for other physiological functions like inhibition of growth of cancer cells and protection against certain immune mediated disorders.

Autres remarques

  • Information on expiry, storage, and usage is provided in the NIST certificate.
  • Notes on Biomaterials, disposal, and transport are available on NIST MSDS.

Notes préparatoires

  • The vials should be stored in the dark at a temperature between –20 °C and –80 °C.
  • Before use, the vial/s must be thawed at room temperature for about 30 mins in subdued light.

Informations légales

NIST is a registered trademark of National Institute of Standards and Technology
SRM is a registered trademark of National Institute of Standards and Technology

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


Certificats d'analyse (COA)

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