60010

Kaempferol

≥97.0% (HPLC)

• Synonyme(s) : 3,4′,5,7-Tetrahydroxyflavone, 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one, Robigenin
• Formule empirique (notation de Hill) : C₁₅H₁₀O₆
• CAS Number: 520-18-3
• Poids moléculaire : 286.24
• Beilstein: 304401
• Numéro MDL: MFCD00016938
• Code UNSPSC : 12352205
• ID de substance PubChem : 57651711
• Nomenclature NACRES : NA.47

Propriétés

• Niveau de qualité: 100
• Essai: ≥97.0% (HPLC)
• Impuretés: ≤12% water
• Application(s): metabolomics; vitamins, nutraceuticals, and natural products
• Chaîne SMILES: Oc1ccc(cc1)C2=C(O)C(=O)c3c(O)cc(O)cc3O2
• InChI: 1S/C15H10O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,16-18,20H
• Clé InChI: IYRMWMYZSQPJKC-UHFFFAOYSA-N
• Informations sur le gène: human ... CDC2(983), CDK5(1020), CDK6(1021), CYP1A2(1544), CYP2C9(1559), GSK3A(2931) ; mouse ... Hexa(15211)

Description

Description générale

Kaempferol is a polyphenolic antioxidant abundantly present in vegetables and fruits. It has a diphenylpropane structure. In many plants, it is present as a glycosidic form namely, kaempferol-3-O-glucoside.

Application

Chromogenic reagent for antimony in the low ppm range and for gallium and indium in the sub-ppm range.

Kaempferol has been used:

• to test its effect on osteoblast proliferation, migration, and differentiation in mouse pre-osteoblast cell line (MC3T3-E1 cells)
• as an antioxidant and a hepatoprotective agent against zearalenone (ZEA)-induced oxidative stress and apoptosis in HEPG2 cells
• as a neuroprotective agent against cadmium chloride (CdCl₂) induced hippocampal damage and memory deficits in rats
• as an anti-inflammatory agent, together with apigenin, for stem-cell therapy on knee osteoarthritic male rats

Actions biochimiques/physiologiques

Kaempferol is hydrophobic in nature due to its diphenylpropane group. It exerts anti-inflammatory actions along with their antioxidant properties and modulates pro-inflammatory enzyme activities. Kaempferol acts as a chemopreventive agent by exerting protective effects on cell viability. It modulates several key elements of cellular signal transduction pathways linked to apoptosis, angiogenesis, metastasis, and inflammation.

Potent inhibitor of osteoclastic bone resorption. The effect is believed to be attributable to both the antioxidant and estrogenic activities of kaempferol.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302
• Conseils de prudence: P264 - P270 - P301 + P312 - P501
• Classification des risques: Acute Tox. 4 Oral
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges