C4915

S-(+)-Chlorpheniramine maleate salt

• Synonyme(s) : (S)-γ-(4-Chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine maleate salt
• Formule empirique (notation de Hill) : C₁₆H₁₉ClN₂ · C₄H₄O₄
• CAS Number: 2438-32-6
• Poids moléculaire : 390.86
• Numéro CE : 219-450-6
• Numéro MDL: MFCD00079046
• Code UNSPSC : 12352116
• ID de substance PubChem : 24278317
• Nomenclature NACRES : NA.77

Propriétés

• Forme: powder
• Niveau de qualité: 200
• Auteur: Bayer
• Chaîne SMILES: [H]\C(=C(/[H])C(O)=O)C(O)=O.CN(C)CC[C@@H](c1ccc(Cl)cc1)c2ccccn2
• InChI: 1S/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t15-;/m0./s1
• Clé InChI: DBAKFASWICGISY-DASCVMRKSA-N
• Informations sur le gène: human ... HRH1(3269)

Description

Description générale

Chlorpheniramine maleate is a cationic amphiphilic anti-histamine agent, which is composed of a hydrophobic ring structure and a hydrophilic side chain with a charged cationic amino group.

Application

S-(+)-Chlorpheniramine maleate salt has been used to study the anticholinergic effect of Achillea millefolium and Portulaca olerace on muscarinic receptors of guinea pig tracheal smooth muscle.

Actions biochimiques/physiologiques

H₁ histamine receptor antagonist; active isomer.
Chlorpheniramine maleate is clinically used as a topical ointment to treat skin disorders such as sunburn, urticaria, angioedema, pruritus and insect bites.

Caractéristiques et avantages

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H301
• Conseils de prudence: P264 - P270 - P301 + P310 - P405 - P501
• Classification des risques: Acute Tox. 3 Oral
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges