E9406

Epirubicin hydrochloride

≥90% (HPLC)

• Synonyme(s) : 4′-Epidoxorubicin hydrochloride, Epidoxorubicin hydrochloride
• Formule empirique (notation de Hill) : C₂₇H₂₉NO₁₁ · HCl
• CAS Number: 56390-09-1
• Poids moléculaire : 579.98
• Numéro CE : 260-145-2
• Numéro MDL: MFCD00941448
• Code UNSPSC : 51102829
• ID de substance PubChem : 329799084
• Nomenclature NACRES : NA.85

Propriétés

• Source biologique: synthetic
• Niveau de qualité: 100
• Essai: ≥90% (HPLC)
• Forme: powder
• Couleur: red to deep red
• Solubilité: H₂O: soluble
• Spectre d'activité de l'antibiotique: neoplastics
• Mode d’action: DNA synthesis | interferes; enzyme | inhibits
• Température de stockage: −20°C
• Chaîne SMILES: Cl.COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO
• InChI: 1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22-,27-;/m0./s1
• Clé InChI: MWWSFMDVAYGXBV-FGBSZODSSA-N

Description

Application

Epirubicin is used to inhibit topoisomerase II and DNA helicase activity. Epirubicin is used to study metastatic breast cancerand cardiac toxicity.

Actions biochimiques/physiologiques

Cell-permeable anthracycline antitumor antibiotic. Antineoplastic. A stereoisomer of doxorubicin that exhibits reduced cardiotoxicity. Its antitumor actions are mediated by targeting topoisomerase II.

Epirubicin is antimitotic and cytotoxic. It inhibits nucleic acid and protein synthesis. Epirubicin may do so by forming complexes with DNA and intercalation between base pairs, by inhibiting topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, and by preventing the religation portion of the ligation-religation reaction that topoisomerase II catalyzes.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07
• Mention d'avertissement: Danger
• Mentions de danger: H302,H340,H350,H360
• Conseils de prudence: P201 - P301 + P312 + P330 - P308 + P313
• Classification des risques: Acute Tox. 4 Oral - Carc. 1B - Muta. 1B - Repr. 1B
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves