F1678

R-(−)-Fluoxetine hydrochloride

>98% (HPLC), solid

• Synonyme(s) : (R)-N-Methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propylamine hydrochloride
• Formule empirique (notation de Hill) : C₁₇H₁₈NOF₃ · HCl
• CAS Number: 114247-09-5
• Poids moléculaire : 345.79
• Numéro MDL: MFCD04040065
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278433
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: >98% (HPLC)
• Forme: solid
• Conditions de stockage: desiccated
• Couleur: white
• Solubilité: H₂O: soluble >10 mg/mL
• Auteur: Eli Lilly
• Chaîne SMILES: Cl[H].CNCC[C@@H](Oc1ccc(cc1)C(F)(F)F)c2ccccc2
• InChI: 1S/C17H18F3NO.ClH/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20;/h2-10,16,21H,11-12H2,1H3;1H/t16-;/m1./s1
• Clé InChI: GIYXAJPCNFJEHY-PKLMIRHRSA-N
• Informations sur le gène: human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363)

Description

Application

R-(−)-Fluoxetine hydrochloride has been used as a serotonin reuptake inhibitor:

• to study its effects on the embryoid body (EB) morphogenesis
• in combination with muscimol hydrobromide (MUS) as well as individually to study its neurotoxic effects on neuronal cells grown on multielectrode array (MEA) chips
• to study its effects as an endocrine disruption inducer in Pimephales promelas

Actions biochimiques/physiologiques

Fluoxetine exhibits anti-depressant activity by increasing the serotonin levels in the neuron synaptic space. It also exhibits therapeutic effects against depression and other mood disorders.

Selective serotonin reuptake inhibitor.

Caractéristiques et avantages

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS05,GHS07
• Mention d'avertissement: Danger
• Mentions de danger: H302,H315,H318
• Conseils de prudence: P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 + P310
• Classification des risques: Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves