H3023

20-Hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoic acid

≥90% (HPLC), liquid, Ras/MAP pathway activitor

• Synonyme(s) : 20-HETE, 20-Hydroxyarachidonic acid
• Formule empirique (notation de Hill) : C₂₀H₃₂O₃
• CAS Number: 79551-86-3
• Poids moléculaire : 320.47
• Numéro MDL: MFCD00171542
• Code UNSPSC : 12352106
• ID de substance PubChem : 24895546
• Nomenclature NACRES : NA.77

Propriétés

• Product Name: 20-Hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoic acid, ~100 μg/mL in ethanol, ≥90% (HPLC)
• Niveau de qualité: 200
• Essai: ≥90% (HPLC)
• Forme: liquid
• Concentration: ~100 μg/mL in ethanol
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Chaîne SMILES: OCCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O
• InChI: 1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10-
• Clé InChI: NNDIXBJHNLFJJP-DTLRTWKJSA-N

Description

Actions biochimiques/physiologiques

20-Hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoic acid (20-HETE) is an arachidonic acid metabolite via cytochrome P4504A, that is an activator of the Ras/MAP (microtubule-associated protein) pathway. 20-HETE acid is a predominant arachidonic acid present in the kidney. It is involved in the regulation of sodium, potassium and chloride transport in the renal tubules. 20-HETE is often excreted in urine in the form of glucuronide conjugate and sometimes as free acids. Increased urine 20-HETE is observed during pregnancy in rats.

Conditionnement

Packaged under argon.

Informations sur la sécurité

• Pictogrammes: GHS02,GHS07
• Mention d'avertissement: Danger
• Mentions de danger: H225,H319
• Conseils de prudence: P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338
• Classification des risques: Eye Irrit. 2 - Flam. Liq. 2
• Code de la classe de stockage: 3 - Flammable liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): 57.2 °F - closed cup
• Point d'éclair (°C): 14.0 °C - closed cup
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)