H9636

Hypoxanthine

powder, suitable for cell culture, BioReagent

• Synonyme(s) : 6-Hydroxypurine
• Formule empirique (notation de Hill) : C₅H₄N₄O
• CAS Number: 68-94-0
• Poids moléculaire : 136.11
• Beilstein: 5811
• Numéro CE : 200-697-3
• Numéro MDL: MFCD00005725
• Code UNSPSC : 12352207
• ID de substance PubChem : 24895864
• Nomenclature NACRES : NA.75

Propriétés

• Product Name: Hypoxanthine, powder, BioReagent, suitable for cell culture
• Gamme de produits: BioReagent
• Essai: ≥99%
• Forme: powder
• Technique(s): cell culture | mammalian: suitable
• Pf: >300 °C (lit.)
• Solubilité: formic acid: water (2:1): 50 mg/mL
• Chaîne SMILES: O=C1NC=Nc2nc[nH]c12
• InChI: 1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)
• Clé InChI: FDGQSTZJBFJUBT-UHFFFAOYSA-N

Description

Description générale

Hypoxanthine (6-hydroxypurine), a purine derivative is a naturally occurring compound. It is the deaminated form of adenine and a breakdown product of adenosine monophosphate (AMP).

Application

Hypoxanthine is a nutrient additive for a variety of cell culture applications involving bacterial, parasite (Plasmodium falciparum) and animal cells. Hypoxanthine is a component of selection media used in hybridoma technologies.

Hypoxanthine has been used:

• as a supplement in HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid) -buffered Roswell park memorial institute (RPMI) to culture Plasmodium falciparum strain IT/FCR3
• in the preparation of Dulbecco′s modified eagle′s medium (DMEM) + MXH for the selection of chimeric modified vaccinia virus ankara (MVA)
• to generate superoxide anions
• to prepare hybridoma selection and maintenance media.

Actions biochimiques/physiologiques

Hypoxanthine is capable of stimulating cell death. It can also induce reactive oxygen species (ROS). It results in endothelial dysfunction via apoptosis, stimulated by oxidative stress.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)