I7378

Indomethacin

98.5-100.5% (in accordance with EP), powder or crystals, COX inhibitor

• Synonyme(s) : 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetic acid
• Formule empirique (notation de Hill) : C₁₉H₁₆ClNO₄
• CAS Number: 53-86-1
• Poids moléculaire : 357.79
• Beilstein: 497341
• Numéro CE : 200-186-5
• Numéro MDL: MFCD00057095
• Code UNSPSC : 12161501
• ID de substance PubChem : 24278173
• Nomenclature NACRES : NA.77

Propriétés

• Product Name: Indomethacin, 98.5-100.5% (in accordance with EP)
• Source biologique: synthetic
• Niveau de qualité: 200
• Essai: 98.5-100.5% (in accordance with EP)
• Forme: powder or crystals
• Perte: ≤0.5% loss on drying
• Pf: 158-162 °C
• Mode d’action: enzyme | inhibits
• Chaîne SMILES: COc1ccc2n(c(C)c(CC(O)=O)c2c1)C(=O)c3ccc(Cl)cc3
• InChI: 1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)
• Clé InChI: CGIGDMFJXJATDK-UHFFFAOYSA-N
• Informations sur le gène: human ... ALB(213), ALOX5(240), ELA2(1991), GPR44(11251), IL1A(3552), PLA2G1B(5319), PTGDR(5729), PTGS1(5742), PTGS2(5743) ; mouse ... Alox5(11689), Ptgdr(19214), Ptger1(19216), Ptger2(19217), Ptger3(19218), Ptger4(19219), Ptgs1(19224) ; rat ... Alox5(25290), Ptgs1(24693), Ptgs2(29527)

Description

Description générale

Indomethacin is an inhibitor of the enzyme cyclooxygenase 1 and 2. Indomethacin elicits side effects in gastrointestinal tract, kidney and cerebrum. Indomethacin, along with ibuprofen, is effective for treating patent ductus arteriosus (PDA) in infants with respiratory distress syndrome. Rectal indomethacin is effective in treating endoscopic retrograde cholangiography (ERCP) induced pancreatitis.

Application

Indomethacin has been used:

• as a medium supplement in osteogenic and adipogenic differentiation assays in human bone marrow stem cells
• as a medium supplement in bovine amniotic fluid stem cells (BAFSCs) culture
• in the inhibition of prostaglandin E2 (PGE2) in T cells

Actions biochimiques/physiologiques

Cyclooxygenase (COX) inhibitor that is relatively selective for COX-1.

Caractéristiques et avantages

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This compound is featured on the Prostanoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H300
• Conseils de prudence: P264 - P270 - P301 + P310 - P405 - P501
• Classification des risques: Acute Tox. 1 Oral
• Code de la classe de stockage: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges