P3782

L-α-phosphatidylcholine

solution, from soybean, suitable for cell culture, Type III-S

• Synonyme(s) : 1,2-diacyl-sn-glycéro-3-phosphocholine, 3-sn-phosphatidylcholine, L-α-lécithine, Asolectine, PC
• CAS Number: 8002-43-5
• Beilstein: 5209585
• Code UNSPSC : 12352211
• Nomenclature NACRES : NA.75

Propriétés

• Source biologique: soybean
• Type: Type III-S (III is the third type of Phosphatidylcholines produced; S is for Soybean.)
• Essai: ≥98%
• Forme: solution
• Concentration: 100 mg/mL in chloroform
• Technique(s): cell culture | mammalian: suitable
• Température de stockage: −20°C
• Chaîne SMILES: [P](=O)([O-])(OC[C@H](OC(=O)CCCCCCC\C=C/C\C=C/CCCCC)COC(=O)CCCCCCCCCCCCCCC)OCC[N+](C)(C)C
• InChI: 1S/C42H80NO8P/c1-6-8-10-12-14-16-18-20-21-23-25-27-29-31-33-35-42(45)51-40(39-50-52(46,47)49-37-36-43(3,4)5)38-48-41(44)34-32-30-28-26-24-22-19-17-15-13-11-9-7-2/h14,16,20-21,40H,6-13,15,17-19,22-39H2,1-5H3/b16-14-,21-20-/t40-/m1/s1
• Clé InChI: JLPULHDHAOZNQI-ZTIMHPMXSA-N

Description

Description générale

Phosphatidylcholine is a phospholipid comprising a choline head group and is associated with organelle membrane and cytomembrane.[1]

Application

L-α-Phosphatidylcholine has been used in phospholipid solid phase enzyme-linked immunosorbent assay (ELISA) to test its interaction with Factor VIII variants (N0 and N6).[2] It has also been used in the synthesis of phosphatidylcholine hydroperoxide (PCOOH) substrate for the glutathione peroxidase (GPx4) assay.[3]

Actions biochimiques/physiologiques

C'est un phospholipide structural important du cerveau, qui représente environ 15 % des lipides totaux et qui est principalement localisé dans la substance grise.

Phosphatidylcholine is essential for acetylcholine synthesis[4] and is crucial for very-low-density lipoprotein secretion in hepatocytes.[5] The pathophysiology of non-alcoholic fatty liver disease (NAFLD) displays a variation in the hepatic PC to phosphatidylethanolamine (PE) ratio.[5] PC alleviates inflammation in ulcerative colitis (UC)[6] and its administration is effective for treating benign symmetric lipomatosis.[7]

Notes préparatoires

Prepared Chromatographically.
Prepared by a modification of the procedure of Singleton, W.S., et al., J. Am. Oil Chem. Soc., 42, 53 (1965).

Informations sur la sécurité

• Pictogrammes: GHS06,GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H302,H315,H319,H331,H336,H351,H361d,H372
• Conseils de prudence: P202 - P301 + P312 - P302 + P352 - P304 + P340 + P311 - P305 + P351 + P338 - P308 + P313
• Classification des risques: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3
• Organes cibles: Central nervous system, Liver,Kidney
• Code de la classe de stockage: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter