R6520

Rolipram

≥98% (HPLC), solid, cAMP-specific phosphodiesterase (PDE4) inhibitor

• Synonyme(s) : 4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone, ZK 62711
• Formule empirique (notation de Hill) : C₁₆H₂₁NO₃
• CAS Number: 61413-54-5
• Poids moléculaire : 275.34
• Numéro CE : 262-771-1
• Numéro MDL: MFCD00270906
• Code UNSPSC : 41106305
• ID de substance PubChem : 24278196
• Nomenclature NACRES : NA.77

Propriétés

• Product Name: Rolipram, solid, ≥98% (HPLC)
• Source biologique: synthetic (organic)
• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: solid
• Couleur: white to off-white
• Solubilité: H₂O: 0.2 mg/mL; ethanol: 7 mg/mL; DMSO: 7.3 mg/mL
• Chaîne SMILES: COc1ccc(cc1OC2CCCC2)C3CNC(=O)C3
• InChI: 1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)
• Clé InChI: HJORMJIFDVBMOB-UHFFFAOYSA-N
• Informations sur le gène: human ... LITAF(9516), PDE3A(5139), PDE4A(5141), PDE4B(5142), PDE4C(5143), PDE4D(5144), PDE5A(8654), PDE7A(5150) ; mouse ... Pde4a(18577) ; rat ... Adora1(29290), Pde1b(29691), Pde2a(81743), Pde3a(50678), Pde4a(25638), Pde4b(24626), Pde4c(290646), Pde5a(171115)

Description

Description générale

Rolipram enhances tissue protection, anatomical repair and functional recovery. It is used to treat asthma, arthritis, Huntington′s disease and multiple sclerosis. Rolipram inhibits injury-induced reductions in cyclic AMP, which is associated with acute central nervous system injury. It functions as an antidepressant, stimulates neurite outgrowth and axonal regeneration in the presence of myelin inhibitors.

Application

Rolipram has been used:

• to investigate its effects on testicular torsion–detorsion injury(36)
• to block the effects of phosphodiesterase-4 (PDE4)(37)
• as a component in chemically induced long-term potentiation (cLTP) induction media(38)

Actions biochimiques/physiologiques

Selective cAMP-specific phosphodiesterase (PDE4) inhibitor.

Caractéristiques et avantages

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves