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SAB4200743

Sigma-Aldrich

Anti-Human IgG (Fc specific)-Peroxidase antibody, Mouse monoclonal

clone HP-6017, purified from hybridoma cell culture

Synonyme(s) :

Anti-Immunoglubulin G (Fc specific)

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.46

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Source biologique

mouse

Niveau de qualité

Conjugué

peroxidase conjugate

Forme d'anticorps

purified from hybridoma cell culture

Type de produit anticorps

primary antibodies

Clone

HP-6017, monoclonal

Forme

lyophilized powder

Espèces réactives

human

Concentration

~2 mg/mL

Technique(s)

ELISA: 1:80,000-1:160,000 using 5 μg/mL Human IgG myeloma for coating

Comparer avec des articles similaires

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Montrer les différences

1 of 4

Cet article
SAB4200790SAB4200791SAB4200755
clone

HP-6017, monoclonal

clone

GG-7, monoclonal

clone

GG-6, monoclonal

clone

GE-1, monoclonal

species reactivity

human

species reactivity

human

species reactivity

human

species reactivity

human

antibody form

purified from hybridoma cell culture

antibody form

purified from hybridoma cell culture

antibody form

purified from hybridoma cell culture

antibody form

purified from hybridoma cell culture

biological source

mouse

biological source

mouse

biological source

mouse

biological source

mouse

conjugate

peroxidase conjugate

conjugate

peroxidase conjugate

conjugate

peroxidase conjugate

conjugate

peroxidase conjugate

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

Description générale

Anti-Human IgG (Fc specific)-Peroxidase antibody, Mouse monoclonal (mouse IgG2a isotype) is derived from the HP-6017 hybridoma, produced by the fusion of mouse myeloma cells and splenocytes from a mouse immunized with purified human IgG myeloma proteins covalently coupled to poly aminostyrene (PAS) microbeads. IgGs (Immunoglobulin G) are the most common Immunoglobulin′s isotype in blood, lymph, cerebrospinal and peritoneal fluids and serve as key players in the humoral immune response. IgGs include four subclasses (IgG1, IgG2, IgG3, and IgG4), consist of a variable Fab fragment (which includes the antibody recognition site) and a conserved Fc fragment.

Immunogène

Human IgG myeloma proteins

Application

Anti-Human IgG (Fc specific)-Peroxidase antibody has been used in enzyme linked immunosorbent assay (ELISA).

Actions biochimiques/physiologiques

IgG (Immunoglobulin G) deficiencies are often associated with various diseases. The Fc fragment has various important functions (e.g complement fixation, site for rheumatoid factor attachment and protein A binding) which indicate on the importance of immunoreagents specific for the Fc fragment of Human IgG.

Forme physique

Supplied as a lyophilized powder.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


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    Consulter la Bibliothèque de documents

    Katherine A McLaughlin et al.
    Journal of immunology (Baltimore, Md. : 1950), 183(6), 4067-4076 (2009-08-19)
    Multiple sclerosis (MS) typically manifests in early to mid adulthood, but there is increasing recognition of pediatric-onset MS, aided by improvements in imaging techniques. The immunological mechanisms of disease are largely unexplored in pediatric-onset MS, in part because studies have
    N Ronda et al.
    Clinical and experimental immunology, 109(1), 211-216 (1997-07-01)
    Interactions between circulating IgG and endothelial cells (EC) in humans have been described only in conditions associated with pathologic immunoglobulins and/or activated or damaged EC. In this study we provide evidence that normal human IgG includes one/some antibody species that
    R Jefferis et al.
    Immunology letters, 10(3-4), 223-252 (1985-01-01)
    Seventy-four monoclonal antibodies (McAb) of putative specificity for human IgG (11), the IgG sub-classes (59) or Gm allotypes (4) have been evaluated for reactivity and specificity in eight laboratories employing different assay techniques or protocols. For the IgG, IgG3, IgG4
    Marta Baranowska et al.
    Vaccine, 33(49), 6988-6996 (2015-09-22)
    Vaccination is at present the most efficient way of preventing influenza infections. Currently used inactivated influenza vaccines can induce virus-neutralizing antibodies that are protective against a particular influenza strain, but hamper the induction of cross-protective T-cell responses to later infections.
    R Jefferis et al.
    Annales de biologie clinique, 52(1), 57-65 (1994-01-01)
    Secondary systemic immune responses are predominantly of the IgG class and passive administration of intravenous IgG, from pooled normal serum, is an effective prophylactic and/or therapeutic treatment for patients with defined immunodeficiencies. However, the proportions of each IgG subclass present

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