136123

trans-Chalcone

97%

• Synonym(s): Benzylideneacetophenone
• Linear Formula: C₆H₅CH=CHCOC₆H₅
• CAS Number: 614-47-1
• Molecular Weight: 208.26
• EC Number: 210-383-8
• MDL number: MFCD00003082
• UNSPSC Code: 12352100
• PubChem Substance ID: 24848257
• NACRES: NA.22

Properties

• Quality Level: 100
• Assay: 97%
• form: solid
• bp: 208 °C/25 mmHg (lit.)
• mp: 55-57 °C (lit.)
• functional group: ketone; phenyl
• SMILES string: [H]\C(=C(\[H])C(=O)c1ccccc1)c2ccccc2
• InChI: 1S/C15H12O/c16-15(14-9-5-2-6-10-14)12-11-13-7-3-1-4-8-13/h1-12H/b12-11+
• InChI key: DQFBYFPFKXHELB-VAWYXSNFSA-N
• Gene Information: human ... IL1B(3553) ; rat ... Ar(24208)

Description

General description

trans-Chalcone is an open chain flavonoid that may prevent lung and forestomach cancer.

Application

trans-Chalcone was used in the synthesis of cis and trans diphenyl cyclopropane. It was also used in screening of surface adsorbed species of isobutybenzene and 4-isobutylacetophenone on bulk fosfotungstic Wells-Dawson acid (H₆P₂W₁₈O₆₂.xH₂O).

Biochem/physiol Actions

trans-Chalcone exhibits antifungal activity against Trichophyton rubrum. It is inhibitor of fatty acid synthase and α-amylase. It induces programmed cell death due to reduced mitochondrial transmembrane potential in Arabidopsis thaliana roots.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302,H319,H335
• Precautionary Statements: P261 - P264 - P270 - P271 - P301 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves