764787
Poly(lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly(lactide-co-glycolide)
average Mn (1,000-1,000-1,000), lactide:glycolide 50:50
Synonym(s):
PLGA-PEG-PLGA
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About This Item
UNSPSC Code:
12162002
NACRES:
NA.23
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description
typical PEG PDI<1.1; overall PDI<1.2 (THF, PEO)
form
liquid
feed ratio
lactide:glycolide 50:50
mol wt
PEG average Mn 1,000
PLGA average Mn 2000
average Mn (1,000-1,000-1,000)
degradation timeframe
1-2 weeks
PDI
<1.2
storage temp.
2-8°C
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General description
PLGA-PEG-PLGA is an amphiphilic triblock copolymer which can self-assemble into micelles in aqueous medium due to the hydrophobic interactions present in the hydrophobic segments. The PEG segment imparts hydrophilicity and improves the biocompatibility of the copolymer. The PLGA segment forms a hydrophobic core and can solubilize hydrophobic drugs. These copolymers are widely used as nanocarriers for the sustained release of drugs.
Application
Used in the synthesis of targeted nanoparticles which are used for differential delivery and controlled release of drugs.
Features and Benefits
Biocompatible, degradable, thermosensitive, high stability, small size (<200 nm) and properties can be easily modified.
Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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