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911429

Sigma-Aldrich

Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide)

PEG average Mn 5,000, PLGA average Mn 5,000, lactide:glycolide 80:20

Synonym(s):

PEG-PLGA, PEG5K-PLGA5K, Polyethylene glycol, mPEG-b-PLGA

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About This Item

Linear Formula:
H[(C3H4O2)x(C2H2O2)y]mO[C2H4O]nCH3
UNSPSC Code:
12352112
NACRES:
NA.23

form

powder

feed ratio

lactide:glycolide 80:20

mol wt

PEG average Mn 5,000 (by NMR)
PLGA average Mn 5,000 (by NMR)

impurities

≤500 ppm (GC)

color

white

storage temp.

−20°C

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Application

This polymer is a amphiphilic diblock copolymer composed of a hydrophilic PEG block and a hydrophobic PLGA block. This biodegradable, biocompatible polymers can self-assemble to form nanoparticles, such as micelles and polymersomes, in both aqueous and non-aqueous media. Due to these properties, these polymers are widely used in polymeric nanoparticle formulation to achieve controlled and targeted delivery of therapeutic agents (e.g. APIs, genetic material, peptides, vaccines, and antibiotics). Additionally, well-defined nanoparticles with tunable size and properties can be prepared by altering the molecular weight ratios between hydrophilic and hydrophobic blocks, as well as by controlling formulation parameters.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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