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G8503

Sigma-Aldrich

18α-Glycyrrhetinic acid

≥95%

Synonym(s):

18α-Glycyrrhetic acid, 18-Isoglycyrrhetinic acid, 3β-Hydroxy-11-oxo-18α,20β-olean-12-en-29-oic acid

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100 μG
₹54,582.00

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100 μG
₹54,582.00

About This Item

Empirical Formula (Hill Notation):
C30H46O4
CAS Number:
1449-05-4
Molecular Weight:
470.68
EC Number:
215-907-9
MDL number:
MFCD00064897
UNSPSC Code:
12352115
PubChem Substance ID:
57654221
NACRES:
NA.22

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Quality Level

100

Assay

≥95%

SMILES string

[H][C@]12C[C@](C)(CC[C@]1(C)CC[C@]3(C)C2=CC(=O)C4[C@@]5(C)CC[C@H](O)C(C)(C)[C@]5([H])CC[C@@]34C)C(O)=O

InChI

1S/C30H46O4/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(25)32)20(31)16-18-19-17-27(4,24(33)34)13-12-26(19,3)14-15-29(18,30)6/h16,19,21-23,32H,8-15,17H2,1-7H3,(H,33,34)/t19-,21+,22+,23-,26-,27+,28+,29-,30-/m1/s1

InChI key

MPDGHEJMBKOTSU-PMTKVOBESA-N

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T1539

(+)-α-Tocopherol

technique(s)

cell culture | insect: suitable

technique(s)

-

technique(s)

-

technique(s)

cell culture | insect: suitable

biological source

plant

biological source

plant

biological source

synthetic

biological source

vegetable oil

form

liquid (or semi-solid)

form

oil or semi-solid

form

liquid

form

liquid (≥0.88M based on potency, density and molecular wt.)

solubility

chloroform: soluble 50 mg/mL, clear, colorless to yellow

solubility

-

solubility

-

solubility

chloroform: soluble 0.1 mL/mL, clear, faintly yellow to yellow

storage temp.

room temp

storage temp.

room temp

storage temp.

2-8°C

storage temp.

2-8°C

color

white to yellow

color

yellow

color

-

color

yellow-orange

General description

18α-Glycyrrhetinic acid (18α-GA) is a bioactive triterpenoid found in licorice.[1] It shows selective inhibition of 11-HSD1 (11-hydroxysteroid dehydrogenase 1).[2] It also shows anti-proliferative and apoptotic effect on hepatic stellate cells (HSCs).[3]

Application

18α-Glycyrrhetinic acid may be used to synthesize:[4]
  • 3-keto-18α-glycyrrhetinic acid
  • methyl esters of 18α-glycyrrhetinic acid
  • methyl esters of 3-keto-18α-glycyrrhetinic acid

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P301 + P312 + P330

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCF2180
BCCD9600
BCCD0515
BCCC3566
BCCB4694

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