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215901

Sigma-Aldrich

Carbonic Anhydrase IX/XII Inhibitor II, U-104

The Carbonic Anhydrase IX/XII Inhibitr II, U-104 controls the biological activity of Carbonic Anhydrase IX/XII. This small molecule/inhibitor is primarily used for Cancer applications.

Synonym(s):

Carbonic Anhydrase IX/XII Inhibitor II, U-104, CAIX Inhibitor II

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₹21,390.00

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About This Item

Empirical Formula (Hill Notation):
C13H12FN3O3S
Molecular Weight:
309.32
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77

₹21,390.00


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Quality Level

Assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 50 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

Fc1ccc(cc1)NC(=O)Nc2ccc(cc2)[S](=O)(=O)N

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assay

>99% (TLC)

assay

>99% (TLC)

assay

>99% (TLC)

assay

>99% (TLC)

packaging

pkg of 1 × 25 mg (850330P-25mg), pkg of 1 × 500 mg (850330P-500mg)

packaging

pkg of 1 × 200 mg (850325P-200mg), pkg of 1 × 25 mg (850325P-25mg)

packaging

pkg of 1 × 2.5 mL (850325C-25mg), pkg of 2 × 4 mL (850325C-200mg)

packaging

pkg of 1 × 2.5 mL (850367C-25mg)

form

powder

form

powder

form

liquid

form

liquid

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

manufacturer/tradename

Avanti Research - A Croda Brand 850330P

manufacturer/tradename

Avanti Research - A Croda Brand 850325P

manufacturer/tradename

Avanti Research - A Croda Brand 850325C

manufacturer/tradename

Avanti Research - A Croda Brand 850367C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

General description

A cell permeable ureido-sulfonamide Carbonic Anhydrase (CA) inhibitor that is selective for human hCA IX and hCA XII (Ki = 45 nM and 4.5 nM, respectively) against two other physiologically relevant hCA isoforms (Ki = 5080 nM and 9640 nM for hCA I and hCA II, respectively). It elicits anti-tumor growth effects dose-dependently from 19 to 38 mg/kg in a mouse tumor growth model implanted with MDA-MB-231 LM2-4Luc+ cells, and demonstrates metastasis inhibition in a mouse metastasis model injected with 4T1 cells.

Packaging

Packaged under inert gas

Warning

Toxicity: Regulatory Review (Z)

Other Notes

Lock, F.E., et al. 2012. Oncogenein press.
Pacchiano, F., et al. 2011. J Med Chem.54, 1896.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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