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About This Item

Empirical Formula (Hill Notation):
C27H27FN2O4
CAS Number:
Molecular Weight:
462.51
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
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Quality Level

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated

color

white

solubility

DMSO: 20 mM

shipped in

ambient

storage temp.

−20°C

SMILES string

FCC(=O)C(NC(=O)C(NC(=O)OCc3ccccc3)Cc2ccccc2)Cc1ccccc1

InChI

1S/C27H27FN2O4/c28-18-25(31)23(16-20-10-4-1-5-11-20)29-26(32)24(17-21-12-6-2-7-13-21)30-27(33)34-19-22-14-8-3-9-15-22/h1-15,23-24H,16-19H2,(H,29,32)(H,30,33)

InChI key

CAILNONEKASNSH-UHFFFAOYSA-N

General description

A potent, cell-permeable and irreversible inhibitor of cathepsin L.
A potent, cell-permeable, and irreversible inhibitor of Cathepsin L (Cat. No. 219402).

Biochem/physiol Actions

Cell permeable: yes
Primary Target
cathepsin L
Product does not compete with ATP.
Reversible: no

Warning

Toxicity: Standard Handling (A)

Sequence

Z-Phe-Phe-CH₂F

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Analysis Note

single spot by TLC

Other Notes

Ravanko, K., et al. 2004. Cancer Res.64, 8831.
Esser, R.E., et al. 1994. Arthritis Rheum. 37, 236.
Shaw, E., et al. 1993. FEBS Lett.334, 340.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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