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324761

Sigma-Aldrich

Elastase Inhibitor V

Synonym(s):

Elastase Inhibitor V, 2-(2-Bromophenyl)-5-chloro-3,1-benzoxazin-4-one

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About This Item

Empirical Formula (Hill Notation):
C14H7BrClNO2
Molecular Weight:
336.57
UNSPSC Code:
12352200
NACRES:
NA.54
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Assay

≥99% (HPLC)

Quality Level

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated
protect from light

color

off-white

solubility

DMSO: 50 mg/mL (Use only fresh DMSO.)

shipped in

ambient

storage temp.

2-8°C

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This Item
21233-U2003720557
material

polyurethane (foam)

material

polyurethane (foam)

material

polyurethane (foam)

material

polyurethane (foam)

agency

EPA 600 (8-80-038)

agency

-

agency

ASTM® D6209, EPA IP-7,TO-13A,TO-4A,TO-9A

agency

ASTM® D4861,D4947, EPA IP-8,TO-10A

technique(s)

active air sampling: suitable

technique(s)

active air sampling: suitable

technique(s)

active air sampling: suitable

technique(s)

active air sampling: suitable

feature

precleaned

feature

precleaned

feature

precleaned

feature

precleaned

description

PUF/XAD-2/PUF Layers; PUFs 25 mm L & 50 mm L; 10 g Amberlite™ XAD™-2

description

PUF/XAD-2/PUF Layers; Each PUF 30 mm L; 1.5g Amberlite™ XAD™-2, assembled

description

Large PUF, assembled

description

Small PUF, assembled

product line

ORBO

product line

ORBO

product line

ORBO

product line

ORBO

General description

A benzoxazinone compound that acts as a potent inhibitor of human leukocyte elastase (IC50 = 29.5 nM), likely by covalently modifying active site serine via a Michael addition-elimination reaction. Shown to inhibit medium elastase activity (IC50 = 80.8 nM), but not O2•- generation, in fLMP (Cat. No. 05-22-2500)-stimulated primary human neutrophil cultures. Reported to reduce neutrophil infiltration in lung after hemorrhagic shock in rats in vivo (1 mg/kg, i.v.) as assessed by increase in lung wet/dry ratio (0.75- vs. 1.23-fold increase, respectively, with or without treatment) and MPO activity (1.08- vs. 3.72-fold increase, respectively, with or without treatment).

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Elastase
Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Hsieh, P.W., et al. 2010. Eur. J. Med. Chem.45, 3111.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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