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400084

Sigma-Aldrich

HIF Prolyl Hydroxylase Inhibitor

Synonym(s):

HIF Prolyl Hydroxylase Inhibitor

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5 ML
₹31,240.00
10 ML
₹58,542.00

₹31,240.00

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5 ML
₹31,240.00
10 ML
₹58,542.00

About This Item

Empirical Formula (Hill Notation):
C21H16ClN3O
CAS Number:
385786-48-1
Molecular Weight:
361.82
MDL number:
MFCD32062494
UNSPSC Code:
12352200
NACRES:
NA.54

₹31,240.00

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Assay

≥95% (HPLC)

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

tan

solubility

DMSO: 50 mg/mL

shipped in

ambient

storage temp.

−20°C

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This Item
506756598472986
Micro particles based on polystyrene size: 3 μm

79166

Micro particles based on polystyrene

Sigma-Aldrich

50675

Micro particles based on polystyrene

Sigma-Aldrich

65984

Micro particles based on polystyrene

Micro particles based on polystyrene size: 10 μm

72986

Micro particles based on polystyrene

particle size

3 μm std dev <0.1 μm, coeff var <3%

particle size

600 nm std dev ≤0.03 μm

particle size

800 nm std dev ≤0.03 μm

particle size

10 μm std dev <0.2 μm, coeff var <2%

form

aqueous suspension

form

aqueous suspension

form

aqueous suspension

form

aqueous suspension

crosslinking

0 % cross-linked

crosslinking

-

crosslinking

-

crosslinking

2 % cross-linked

concentration

10% (solids)

concentration

10% (solids)

concentration

10% (solids)

concentration

10% (solids)

density

1.05 g/cm3

density

1.05 g/cm3

density

1.05 g/cm3

density

1.05 g/cm3

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

General description

A cell-permeable, hydroxyquinoline HIF Prolyl Hydroxylase (PHD) inhibitor that displays an IC50 = 2 µM in a cell-based assay using a reporter produced by fusing HIF-1α oxygen degradable domain (ODD) to luciferase. This compound (5 µM) is shown to significantly stabilize HIF-1α in vitro and upregulate known HIF target genes, Epo and VEGF, in SH-SY5Y human neuroblastoma cell lines. It also exerts a neuroprotective effect (IC50 = 0.25 µM in an oxidative stress model using cortical neurons.

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Smirnova, N.A., et al. 2010. Chem. Biol.4, 380.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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