MAP-2 (microtubule associated protein-2) is one of several high molecular weight proteins that play an important role in brain neuron microtubule assembly. In addition to its association with microtubules, MAP-2 associates with neurofilaments and actin filaments suggesting that it may guide interaction among microtubules, other cytoskeletal elements, and cytoplasmic organelles. MAP-2 is a stringent marker for neurons. In addition, MAP-2 displays intracellular specificity. In the central nervous system, MAP-2 is confined to neuronal cell bodies and dendrites. There are exceptions, however, where some axons stain positive for small amounts of MAP-2. MAP-2 is uniformly distributed throughout the cell when first expressed in cultured neurons but becomes selectively localized as dendritic development proceeds. (Caceres, 1986; Dotti, 1987).

Antibody recognizes MAP-2.

Recombinant Bovine brain microtubule protein.

Milli-Mark Anti-MAP2-PE Antibody, clone AP20 is an antibody against MAP2 for use in FC.

Research Category
Neuroscience

Research Sub Category
Neuronal & Glial Markers

Evaluated by flow cytometry using U251 cells

199.5 kDa Calculated

Protein A purified

Purified mouse monoclonal IgG1 conjugated to PE in PBS with 0.1% sodium azide and 15 mg/mL BSA.

Maintain refrigerated at 2-8°C protected from light for up to 6 months from date of receipt.

Control
U251 cells

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