07964

Methoxypolyethylene glycol amine

750

• Synonym(s): mPEG-NH₂, O-(2-Aminoethyl)-O′-methylpolyethylene glycol, Aminopolyethylene glycol monomethyl ether, Methoxypolyoxyethylene amine
• Linear Formula: H₂NCH₂CH₂(OCH₂CH₂)_nOCH₃
• CAS Number: 80506-64-5
• MDL number: MFCD00131599
• UNSPSC Code: 12162002
• NACRES: NA.22

Properties

• Quality Level: 100
• form: solid
• color: white to yellow
• InChI: 1S/C3H9NO/c1-5-3-2-4/h2-4H2,1H3
• InChI key: ASUDFOJKTJLAIK-UHFFFAOYSA-N

Description

Application

Methoxypolyethylene glycol amine can:

• Form dendritic micelles to enhance the solubility of hydrophobic compounds.
• Conjugate with an anticancer drug methotrexate (MTX) to form MTX-PEG with potential application as drug carriers.
• Couple with polyethylenimine (PEI) to form graft copolymers which can be used as nonviral gene vectors.

Other Notes

Oligomer used to prepare PEG-ylated conjugates having the advantage of reduced immunogenicity and increased serum half life

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves