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A2129

Sigma-Aldrich

γ-Aminobutyric acid

≥99% (TLC), powder or crystals, inhibitory neurotransmitter

Synonym(s):

GABA, Gammalon, gamma-Aminobutyric acid, 3-Carboxypropylamine, 4-Aminobutanoic acid, Piperidic acid, Piperidinic acid

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About This Item

Linear Formula:
NH2(CH2)3COOH
CAS Number:
Molecular Weight:
103.12
Beilstein:
906818
EC Number:
MDL number:
UNSPSC Code:
12352106
PubChem Substance ID:
NACRES:
NA.32

Product Name

γ-Aminobutyric acid, ≥99%

Quality Level

Assay

≥99%

form

powder or crystals

storage condition

(Tightly closed. Dry.)

color

colorless

mp

195 °C (dec.) (lit.)

solubility

water: 50 mg/mL, clear, colorless

SMILES string

NCCCC(O)=O

InChI

1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)

InChI key

BTCSSZJGUNDROE-UHFFFAOYSA-N

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General description

γ-Aminobutyric acid (GABA) is a non-amino protein. It is found in plants, animals, and microorganisms. GABA has been used in pharma and food industries as a component of cheese, shochu, gabaron tea, and gammalone.
Research area: Neuroscience

Application

γ-Aminobutyric acid (GABA) has been used:
  • in the preparation of GABA–BSA (bovine serum albumin)–GA (glutaraldehyde) conjugate, which is used as a control for GABA immunostaining
  • in the macromolecule suppressed detection of GABA by magnetic resonance spectroscopy (MRS)
  • in the intraintestinal application of GABA in order to increase intraluminal fluid secretion

Biochem/physiol Actions

GABA (γ-Aminobutyric acid) is an amino acid that functions as an inhibitory neurotransmitter in the central nervous system and as a neuromodulator in some peripheral tissues. It binds to the GABAA receptor and inhibits the activity of signal-receiving neurons. The GABAA receptors are found to form a channel in the cell membranes of neurons. Upon binding of GABA, the receptor is activated to allow the passage of negatively charged molecules, such as chloride ions, into the cell. This results in a lowering of the excitability of the cell.
GABAergic neurons involve myorelaxation, anxiolytic treatment, sedation, and anesthetics. GABA can also influence heart rate and blood pressure.
GABA improves plasma concentration, growth hormone, and protein synthesis in the brain. It also plays a role in reducing blood pressure in humans. GABA acts as a potent hypotensive, diuretic, and antidiabetic agent. It also regulates serum lipids levels and the sensation of pain.
Major inhibitory neurotransmitter in brain; GABAA and GABAB receptor agonist; increases Cl conductance.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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