A5486

Azoxymethane

13.4 M, ≥98%

• Synonym(s): AOM
• Linear Formula: CH₃N=N(→O)CH₃
• CAS Number: 25843-45-2
• Molecular Weight: 74.08
• MDL number: MFCD00126912
• UNSPSC Code: 12352124
• PubChem Substance ID: 329770827
• NACRES: NA.25

Properties

• Quality Level: 200
• Assay: ≥98%
• form: liquid
• composition: methylene chloride, ≤1%
• storage condition: (Keep container tightly closed in a dry and well-ventilated place.)
• concentration: 13.4 M
• color: colorless
• bp: 97-99 °C (lit.)
• density: 0.991 g/mL at 25 °C (lit.)
• application(s): genomic analysis
• storage temp.: −20°C
• SMILES string: C\N=[N+](/C)[O-]
• InChI: 1S/C2H6N2O/c1-3-4(2)5/h1-2H3/b4-3+
• InChI key: DGAKHGXRMXWHBX-ONEGZZNKSA-N

Description

General description

Azoxymethane (AOM) is a potent laboratory chemical used to study cancer initiation, progression, and prevention, particularly in the colon. It acts as both a carcinogen, triggering tumor formation, and a gene mutation agent, causing specific alterations in DNA.

Application

Azoxymethane (AOM), a gene mutation agent, may be used with dextran sulfate sodium (DSS) to create cancer models in laboratory animals which can be used to study mechanisms of cancer progression and chemoprevention.

Biochem/physiol Actions

Carcinogen that induces O⁶-methylguanine adducts in DNA leading to G→A transitions. Induces tumorigenesis in the colon of laboratory animals and is used to study the mechanism of cancer progression and chemoprevention.

Features and Benefits

Versatile and adaptable for a wide variety of laboratory and research applications.

Other Notes

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It is critical to determine the correct dosage of Azoxymethane for the experimental design to avoid premature death of laboratory animals.

Safety Information

• Pictograms: GHS02,GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H226,H300,H315,H319,H350
• Precautionary Statements: P202 - P210 - P233 - P301 + P310 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 3
• Flash Point(F): 75.2 °F
• Flash Point(C): 24 °C