A6885

Adenosine 3′,5′-cyclic monophosphate sodium salt monohydrate

≥98.0% (HPLC), powder

• Synonym(s): 3′,5′-Cyclic AMP sodium salt, cAMP-Na
• Empirical Formula (Hill Notation): C₁₀H₁₁N₅NaO₆P · H₂O
• CAS Number: 37839-81-9
• Molecular Weight: 369.20
• Beilstein: 54612
• MDL number: MFCD00069736
• UNSPSC Code: 41106305
• eCl@ss: 32160414
• PubChem Substance ID: 24891151
• NACRES: NA.77

Properties

• Quality Level: 200
• Assay: ≥98.0% (HPLC)
• form: powder
• color: white
• solubility: H₂O: 10 mg/mL
• storage temp.: −20°C
• SMILES string: [Na+].Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4COP([O-])(=O)O[C@H]4[C@H]3O
• InChI: 1S/C10H12N5O6P.Na/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7;/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13);/q;+1/p-1/t4-,6-,7-,10-;/m1./s1
• InChI key: BXJBFCKTIWRKMQ-MCDZGGTQSA-M

Description

Application

Adenosine-3′,5′-cyclic monophosphate (cAMP) is an activator of cyclic-AMP-dependent protein kinase A (PKA). The cAMP/PKA signaling pathway has been shown to inhibit cell proliferation, induce differentiation and lead to apoptosis. Exogneous cAMP plays a role in the spontaneous activity and contraction of the heart muscle.

Biochem/physiol Actions

Naturally-occurring activator of cyclic-AMP-dependent protein kinase (PKA).

Naturally-occurring activator of cyclic-AMP-dependent protein kinase (PKA). cAMP is an important second messenger that is linked in many systems to neurotransmitter- or hormone-induced receptor stimulation. The cAMP/PKA signaling pathway has been shown to inhibit cell proliferation, induce differentiation and lead to apoptosis.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Phosphodiesterases and PKA & PKG pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves