Name: Diacylglycerol Kinase Inhibitor II
Brand: SIGMA

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About This Item

Empirical Formula (Hill Notation):

C₂₈H₂₅F₂N₃OS

CAS Number:

120166-69-0

Molecular Weight:

489.58

MDL number:

MFCD00069258

UNSPSC Code:

41106300

PubChem Substance ID:

24278378

NACRES:

NA.77

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biological source

synthetic (organic)

Quality Level

200

Assay

≥97% (HPLC)

form

solid

color

pale yellow

mp

228-230 °C

solubility

0.1 M HCl: slightly soluble
0.1 M NaOH: slightly soluble
DMSO: soluble
H₂O: insoluble
ethanol: soluble
ethyl acetate: soluble

storage temp.

−20°C

SMILES string

Fc1ccc(cc1)\C(=C2\CCN(CCN3C(=S)Nc4ccccc4C3=O)CC2)c5ccc(F)cc5

InChI

1S/C28H25F2N3OS/c29-22-9-5-19(6-10-22)26(20-7-11-23(30)12-8-20)21-13-15-32(16-14-21)17-18-33-27(34)24-3-1-2-4-25(24)31-28(33)35/h1-12H,13-18H2,(H,31,35)

InChI key

ZCNBZFRECRPCKU-UHFFFAOYSA-N

Application

Diacylglycerol Kinase Inhibitor II has been used to determine tumor-induced inhibition with genetically modified cytotoxic T cells expressing chimeric antigen receptors (CAR). It has also been used to induce pAkt and PKR-like extracellular signal-regulated kinase (pErk) signals in T-cell acute lymphoblastic leukemia (T-ALL) cells.

Biochem/physiol Actions

Diacylglycerol kinase inhibitor. Inhibits formation of [³⁸P]1-Oleoyl-2-acetylglyceryl-3-phosphoric acid (OAPA) in red blood cell membranes: IC₅₀ = 3.3 μM.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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