D7692

Diethylumbelliferyl phosphate

≥98% (HPLC), oil

• Synonym(s): DEUP, UBP
• Empirical Formula (Hill Notation): C₁₄H₁₇O₆P
• CAS Number: 897-83-6
• Molecular Weight: 312.25
• UNSPSC Code: 12352200
• PubChem Substance ID: 24894155
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: oil
• color: colorless to yellow
• solubility: DMSO: >5 mg/mL
• storage temp.: −20°C
• SMILES string: CCOP(=O)(OCC)Oc1ccc2C(C)=CC(=O)Oc2c1
• InChI: 1S/C14H17O6P/c1-4-17-21(16,18-5-2)20-11-6-7-12-10(3)8-14(15)19-13(12)9-11/h6-9H,4-5H2,1-3H3
• InChI key: GHGRYKAFUNNHBG-UHFFFAOYSA-N

Description

Application

Diethylumbelliferyl phosphate has been used as a lipase inhibitor to treat wild-type myeloblasts for in vitro neutrophil differentiation assays.

Biochem/physiol Actions

Diethylumbelliferyl phosphate (DEUP), an organophosphate does not block protein kinase activity A in vitro.

Diethylumbelliferyl phosphate is a selective, potent cholesterol esterase inhibitor. It blocks steroidogenesis primarily by preventing cholesterol transport into the mitochondria of steroidogenic cells. Inhibitors of cholesterol esterase are anticipated to limit the absorption of dietary cholesterol. IC₅₀ = 11.6 μM.

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H300
• Precautionary Statements: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 2 Oral
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves