E7138
Ethosuximide
Synonym(s):
2-Ethyl-2-methylsuccinimide
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All Photos(3)
About This Item
Empirical Formula (Hill Notation):
C7H11NO2
CAS Number:
Molecular Weight:
141.17
EC Number:
MDL number:
UNSPSC Code:
12352111
PubChem Substance ID:
NACRES:
NA.77
Recommended Products
Quality Level
solubility
ethanol: 100 mg/mL
SMILES string
O=C1NC(CC1(C)CC)=O
InChI
1S/C7H11NO2/c1-3-7(2)4-5(9)8-6(7)10/h3-4H2,1-2H3,(H,8,9,10)
InChI key
HAPOVYFOVVWLRS-UHFFFAOYSA-N
Gene Information
human ... CACNA1G(8913), CACNA1H(8912), CACNA1I(8911)
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Application
Ethosuximide has been used:
- to confirm its effect on spike wave discharges (SWD) in rats
- to examine its effects on spontaneous locomotion and anxiety-related thigmotaxis behaviours in zebrafish larvae of wild type
- as a model drug for the treatment of epilepsy in vivo(4)
Biochem/physiol Actions
Ethosuximide is an anticonvulsant drug and an antagonist for T-type calcium channel. It is known to prevent spike wave discharges, characterized in absence seizures.
Features and Benefits
This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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