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F2053

Sigma-Aldrich

Fas Intracellular Domain human

>90% (SDS-PAGE), recombinant, expressed in E. coli (N-terminal histidine tagged), buffered aqueous solution

Synonym(s):

APO-1 interacellular domain, CD95 intracellular domain, Fas IC

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About This Item

MDL number:
MFCD00676999
UNSPSC Code:
12352200
NACRES:
NA.77
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recombinant

expressed in E. coli (N-terminal histidine tagged)

Quality Level

200

Assay

>90% (SDS-PAGE)

form

buffered aqueous solution

mol wt

>18.8 kDa

UniProt accession no.

P25445

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... FAS(355)

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This Item
1.591668.187551.01830
Acetic acid 96% for analysis EMSURE®

1.00062

Acetic acid 96%

Acetic acid 30% for analysis EMSURE® Reag. Ph Eur

1.59166

Acetic acid 30%

Acetic acid 99-100% for synthesis

8.18755

Acetic acid 99-100%

Acetic acid (glacial) 100% for analysis EMPARTA® ACS

1.01830

Acetic acid (glacial) 100%

assay

≥96.0% (alkalimetric)

assay

-

assay

≥99% (acidimetric)

assay

≥99.7% (acidimetric)

Quality Level

300

Quality Level

300

Quality Level

200

Quality Level

200

form

liquid

form

liquid

form

liquid

form

liquid

storage temp.

15-25°C

storage temp.

no temp limit

storage temp.

15-25°C

storage temp.

15-25°C

pH

2.5 (20 °C, 10 g/L in H2O)

pH

-

pH

2.5 (20 °C, 50 g/L in H2O)

pH

2.5 (20 °C, 50 g/L in H2O)

density

1.05 g/cm3 at 20 °C

density

1.039 g/cm3 at 20 °C

density

1.04 g/mL at 25 °C (lit.)

density

1.04 g/mL at 25 °C (lit.)

General description

Fas is a key component of apoptosis, and is a cell surface receptor. This gene is localized to human chromosome 10q24.1, and is composed of nine exons and eight introns.[1]

Biochem/physiol Actions

Fas and its ligand play an essential role in apoptosis, by activating the cell death signaling pathway. Mutations in this gene are associated with evasion of apoptosis by cells, leading to tumorigenesis, and prevention of clearance of these cells by the immune system.[1] A polymorphism in this gene results in the production of soluble Fas (sFas), which is implicated in the chronic autoimmune disorder called primary Sjögren′s syndrome (pSS).[2]
Fas intracellular domain, amino acids 191-335, is a widely expressed membrane receptor, which is responsible for controlling tissue homeostasis and immune responses. Fas receptor is activated by Fas ligand causing its trimerization. The aggregated Fas intracellular death domain recruits, via FADD adapter, pro-caspase-8 and forms a DISC (death-inducing signaling complex). Caspase 8, in turn, activates the downstream caspases, such as caspase 3, culminating in apoptosis.
Widely expressed membrane receptor responsible for controlling tissue homeostasis and immune responses.

Physical form

Solution in 50 mM Tris-HCl, pH 8.0, 2 mM EDTA, 2 mM DTT, 300 mM NaCl, 0.05% NP-40, and 10% sucrose.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

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