G4753

Griseofulvin

from Penicillium griseofulvum, 97.0-102.0%

• Synonym(s): (2S)-trans-7-Chloro-2′,4,6-trimethoxy-6′-methylspiro(benzofuran-2[3H],1′-[2]cyclohexene)-3,4′-dione
• Empirical Formula (Hill Notation): C₁₇H₁₇ClO₆
• CAS Number: 126-07-8
• Molecular Weight: 352.77
• Beilstein: 95226
• EC Number: 204-767-4
• MDL number: MFCD00082343
• UNSPSC Code: 12352200
• PubChem Substance ID: 24895185
• NACRES: NA.77

Properties

• biological source: Penicillium griseofulvum
• Quality Level: 100
• Assay: 97.0-102.0%
• form: powder
• antibiotic activity spectrum: fungi
• Mode of action: DNA synthesis | interferes
• storage temp.: −20°C
• SMILES string: ClC1=C(O[C@@]2(C(OC)=CC(C[C@H]2C)=O)C3=O)C3=C(OC)C=C1OC
• InChI: 1S/C17H17ClO6/c1-8-5-9(19)6-12(23-4)17(8)16(20)13-10(21-2)7-11(22-3)14(18)15(13)24-17/h6-8H,5H2,1-4H3/t8-,17+/m1/s1
• InChI key: DDUHZTYCFQRHIY-RBHXEPJQSA-N

Description

Biochem/physiol Actions

Antifungal. Mode of action: Disrupts the mitotic spindle structure and inhibits nuclear division. Induces apoptosis in human tumor cell lines.

Safety Information

• Pictograms: GHS08,GHS07
• Signal Word: Danger
• Hazard Statements: H317,H351,H360FD
• Precautionary Statements: P202 - P261 - P272 - P280 - P302 + P352 - P308 + P313
• Hazard Classifications: Carc. 2 - Repr. 1B - Skin Sens. 1
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves